Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …

Senescent cells (SnCs) are associated with age-related pathologies. Osteoarthritis is a
chronic disease characterized by pain, loss of cartilage, and joint inflammation, and its …

Senescent cells accumulate in human tissues during ageing and contribute to age-related
pathologies. The mechanisms responsible for their accumulation are unclear. Here we show …

Polycomb group (PcG) factors maintain facultative heterochromatin and mediate many
important developmental and differentiation processes. EZH2, a PcG histone H3 lysine-27 …

While global chromatin conformation studies are emerging, very little is known about the
chromatin conformation of human telomeres. Most studies have focused on the role of …

INTRODUCTION How novel protein architectures evolve remains poorly understood. The
rearrangement of domains with preexisting functions into new composite architectures …

Ageing leads to dramatic changes in the physiology of many different tissues resulting in a
spectrum of pathology. Nonetheless, many lines of evidence suggest that ageing is driven …

Abstract Naked mole-rat (NMR), the longest-living rodent, produces very-high-molecular-
mass hyaluronan (vHMM-HA), compared to other mammalian species. However, it is …

Cancer progression is a multifaceted process that entails several stages and demands the
persistent expression or activation of transcription factors (TFs) to facilitate growth and …

Replicative cellular senescence is a fundamental biological process characterized by an
irreversible arrest of proliferation. Senescent cells accumulate a variety of epigenetic …