Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis

M Presta, P Dell'Era, S Mitola, E Moroni… - Cytokine & growth factor …, 2005 - Elsevier
Fibroblast growth factors (FGFs) are a family of heparin-binding growth factors. FGFs exert
their pro-angiogenic activity by interacting with various endothelial cell surface receptors …

A glycobiology review: carbohydrates, lectins and implications in cancer therapeutics

H Ghazarian, B Idoni, SB Oppenheimer - Acta histochemica, 2011 - Elsevier
This review is intended for general readers who would like a basic foundation in
carbohydrate structure and function, lectin biology, and the implications of glycobiology in …

The molecular profile of microglia under the influence of glioma

W Li, MB Graeber - Neuro-oncology, 2012 - academic.oup.com
Microglia, which contribute substantially to the tumor mass of glioblastoma, have been
shown to play an important role in glioma growth and invasion. While a large number of …

Intrathecal inflammation precedes development of Alzheimer's disease

E Tarkowski, N Andreasen, A Tarkowski… - Journal of Neurology …, 2003 - jnnp.bmj.com
Objectives: To analyse the cerebrospinal fluid (CSF) values of the proinflammatory
cytokines, interleukin 1β (IL1β), tumour necrosis factor α (TNFα), GM-CSF, of the anti …

Transforming growth factor-beta: vasculogenesis, angiogenesis, and vessel wall integrity

MS Pepper - Cytokine & growth factor reviews, 1997 - Elsevier
Genetic studies have recently revealed a role for transforming growth factor-beta-1 (TGF-β1)
and its receptors (TGF-βRs I and II as well as endoglin) in embryonic vascular assembly and …

Increased intrathecal levels of the angiogenic factors VEGF and TGF-β in Alzheimer's disease and vascular dementia

E Tarkowski, R Issa, M Sjögren, A Wallin… - Neurobiology of …, 2002 - Elsevier
The aim of the present study was to investigate, in patients with Alzheimer's disease (AD),
and vascular dementia (VAD), patterns of local release of vascular endothelial growth factor …

Transforming growth factor‐β and Smad signalling in kidney diseases

W Wang, V Koka, HY Lan - Nephrology, 2005 - Wiley Online Library
Extensive studies have demonstrated that transforming growth factor‐beta (TGF‐β) plays an
important role in the progression of renal diseases. TGF‐β exerts its biological functions …

Transforming growth factor β1 is associated with angiogenesis, metastasis, and poor clinical outcome in prostate cancer

P Wikström, P Stattin, I Franck‐Lissbrant… - The …, 1998 - Wiley Online Library
BACKGROUND Prostate tumors express high levels of transforming growth factor‐β1 (TGF‐
β1) and seem to acquire resistance to its antiproliferative effects with tumor progression …

On the role of cell surface carbohydrates and their binding proteins (lectins) in tumor metastasis

E Gorelik, U Galili, A Raz - Cancer and Metastasis Reviews, 2001 - Springer
This review focuses on the recent advances in investigations of the role of cell surface
carbohydrates in tumor metastasis. It also summarizes the results of extensive studies of …

Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma

M Zhang, S Kleber, M Röhrich, C Timke, N Han… - Cancer research, 2011 - AACR
Glioblastoma multiforme (GBM) is a highly aggressive primary brain tumor that tends to be
resistant to the ionizing radiotherapy used to treat it. Because TGF-β is a modifier of radiation …