[HTML][HTML] Therapeutic siRNA: state-of-the-art and future perspectives

M Friedrich, A Aigner - BioDrugs, 2022 - Springer
The highly specific induction of RNA interference-mediated gene knockdown, based on the
direct application of small interfering RNAs (siRNAs), opens novel avenues towards …

Developing an immune‐related gene prognostic index associated with progression and providing new insights into the tumor immune microenvironment of prostate …

D Feng, F Zhang, D Li, X Shi, Q Xiong, Q Wei… - …, 2022 - Wiley Online Library
We developed an immune‐related gene prognostic index (IGPI) associated with progression
and provided new insights into the tumour immune microenvironment (TIME) for prostate …

[HTML][HTML] A harmonized resource of integrated prostate cancer clinical,-omic, and signature features

TD Laajala, V Sreekanth, AC Soupir, JH Creed… - Scientific Data, 2023 - nature.com
Genomic and transcriptomic data have been generated across a wide range of prostate
cancer (PCa) study cohorts. These data can be used to better characterize the molecular …

The crucial role of LncRNA MIR210HG involved in the regulation of human cancer and other disease

J Lu, D Zhu, X Zhang, J Wang, H Cao, L Li - Clinical and Translational …, 2023 - Springer
Long noncoding RNAs (lncRNAs) have evoked considerable interest in recent years due to
their critical functions in the regulation of disease processes. Abnormal expression of …

[HTML][HTML] Tyrosine-modification of polypropylenimine (PPI) and polyethylenimine (PEI) strongly improves efficacy of siRNA-mediated gene knockdown

S Noske, M Karimov, A Aigner, A Ewe - Nanomaterials, 2020 - mdpi.com
The delivery of small interfering RNAs (siRNA) is an efficient method for gene silencing
through the induction of RNA interference (RNAi). It critically relies, however, on efficient …

[HTML][HTML] Integrative multi-omics analysis unveils stemness-associated molecular subtypes in prostate cancer and pan-cancer: prognostic and therapeutic significance

K Zheng, Y Hai, Y Xi, Y Zhang, Z Liu, W Chen… - Journal of Translational …, 2023 - Springer
Background Prostate cancer (PCA) is the fifth leading cause of cancer-related deaths
worldwide, with limited treatment options in the advanced stages. The immunosuppressive …

[HTML][HTML] Immune-related gene index predicts metastasis for prostate cancer patients undergoing radical radiotherapy

D Feng, W Zhu, X Shi, Z Wang, W Wei, Q Wei… - … Hematology & Oncology, 2023 - Springer
In this study, we established a novel immunologic gene prognostic index (IGPI) to predict
metastasis and provided new insights into tumor immune microenvironment (TIME) for PCa …

[HTML][HTML] The noncoding RNA LINC00152 conveys contradicting effects in different glioblastoma cells

S Binder, I Zipfel, C Müller, K Wiedemann… - Scientific Reports, 2021 - nature.com
Glioblastoma multiforme (GBM) is an extremely aggressive brain tumor, characterized by its
high genetic heterogeneity. In search of novel putative therapeutic RNA targets we …

[HTML][HTML] Systematic investigation of the mechanism of herbal medicines for the treatment of prostate cancer

J Wang, R Ding, T Ouyang, H Gao, H Kan, Y Li… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Due to various unpleasant side effects and general ineffectiveness of current treatments for
prostate cancer (PCa), more and more people with PCa try to look for complementary and …

Androgen receptor phosphorylated at Ser815: The expression and function in the prostate and tumor-derived cells

K Yokobori, Y Kawasaki, Y Sekine, S Nobusawa… - Biochemical …, 2021 - Elsevier
Androgen is beneficial for the prostate with normal functions but creates a risk for prostate
cancer progression. How androgen receptor (AR) mediates these various androgen actions …