Simple Summary The present article reviews the state of the art of metronomic
chemotherapy use to treat the principal types of cancers, namely breast, non-small cell lung …

While psychological factors have long been linked to breast cancer pathogenesis and
outcomes, accumulating evidence is revealing how the nervous system contributes to breast …

Metronomic chemotherapy (mCHT), defined as continuous administration of low-dose
chemotherapeutic agents with no or short regular treatment-free intervals, was first …

Despite the significant expansion of the therapeutic armamentarium associated with the
introduction of novel endocrine therapies, cytotoxic agents, radiopharmaceuticals, and …

The successful treatment of breast cancer is hampered by toxicity to normal cells, impaired
drug accumulation at the tumor site, and multidrug resistance. We designed a novel …

Atropine (ATR) is extracted from a belladonna plant that belongs to a class of anticholinergic
drugs and is therefore involved in the treatment of the overdose of cholinergic drugs or …

Atropine metabolite as a tropane alkaloid is mainly applied as anticholinergic medication.
Other therapeutic activities such as anticancer and antimicrobial effects have been found for …

Aim: Triple negative breast cancer (TNBC) is usually treated with high doses of paclitaxel,
whose effectiveness may be modulated by the action of environmental contaminants such …

Metronomic chemotherapy (MCT), characterized by the continuous administration of
chemotherapeutics at a lower dose without prolonged drug-free periods, has garnered …

Purpose Cholinergic signals can be important modulators of cellular signaling in cancer. We
recently have shown that knockdown of nicotinic acetylcholine receptor subunit alpha 5 …