CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of
substrates, controls several signaling pathways, and is implicated in a plethora of human …

Pyruvate is irreversibly decarboxylated to acetyl coenzyme A by mitochondrial pyruvate
dehydrogenase complex (PDC). Decarboxylation of pyruvate is considered a crucial step in …

Alzheimer's disease (AD) is the general consequence of dementia and is diagnostic
neuropathology by the cumulation of amyloid-beta (Aβ) protein aggregates, which are …

Protein kinase CK2 has received a surge of attention in recent years due to the evidence of
its overexpression in a variety of solid tumors and multiple myelomas as well as its …

Cancer is a leading cause of death worldwide. Casein kinase 2 (CK2) is commonly
dysregulated in cancer, impacting diverse molecular pathways. CK2 is a highly conserved …

Goat milk is increasingly recognized by consumers due to its high nutritional value, richness
in short-and medium-chain fatty acids, and richness in polyunsaturated fatty acids (PUFA) …

Glioblastoma (GBM) causes poor survival in patients even with aggressive treatment.
Temozolomide (TMZ) is the standard chemotherapeutic choice for GBM treatment but …

Multi-drug resistance (MDR) is a curious bottleneck in cancer research and chemotherapy,
whereby some cells rapidly adapt to the tumor microenvironment via a myriad of …

The use of cisplatin for the treatment of non-small cell lung cancer has long been
constrained by the rapid acquisition of tumor cell chemoresistance. In the present study, we …

Insulin plays a major role in glucose metabolism and insulin-signaling defects are present in
obesity and diabetes. CK2 is a pleiotropic protein kinase implicated in fundamental cellular …