[HTML][HTML] Targeting the mSWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies
Summary The POU2F3-POU2AF2/3 transcription factor complex is the master regulator of
the tuft cell lineage and tuft cell-like small cell lung cancer (SCLC). Here, we identify a …
the tuft cell lineage and tuft cell-like small cell lung cancer (SCLC). Here, we identify a …
[HTML][HTML] PROTACs targeting androgen receptor signaling: potential therapeutic agents for castration-resistant prostate cancer
Y Zhang, A Ming, J Wang, W Chen, Z Fang - Pharmacological Research, 2024 - Elsevier
After the initial androgen deprivation therapy (ADT), part of the prostate cancer may
continuously deteriorate into castration-resistant prostate cancer (CRPC). The majority of …
continuously deteriorate into castration-resistant prostate cancer (CRPC). The majority of …
Evaluation of glucocorticoid-related genes reveals GPD1 as a therapeutic target and regulator of sphingosine 1-phosphate metabolism in CRPC
R Liu, Z Zou, Z Zhang, H He, M Xi, Y Liang, J Ye, Q Dai… - Cancer Letters, 2024 - Elsevier
Prostate cancer (PCa) is an androgen-dependent disease, with castration-resistant prostate
cancer (CRPC) being an advanced stage that no longer responds to androgen deprivation …
cancer (CRPC) being an advanced stage that no longer responds to androgen deprivation …
Discovery of Novel, Potent and Orally Bioavailable SMARCA2 PROTACs with Synergistic Anti-tumor Activity in Combination with KRAS G12C Inhibitors.
S Kotagiri, Y Wang, YY Han, X Liang, N Blazanin… - bioRxiv, 2024 - biorxiv.org
Cancer genomic studies have identified frequent mutations in subunits of the SWI/SNF
chromatin remodeling complex including SMARCA4 in non-small cell lung cancer with a …
chromatin remodeling complex including SMARCA4 in non-small cell lung cancer with a …