Uric acid, generated from the metabolism of purines, has proven and emerging roles in
human disease. Serum uric acid is determined by production and the net balance of …

Uric acid is the metabolic end product of purine metabolism in humans. It has antioxidant
properties that may be protective but can also be pro-oxidant, depending on its chemical …

Chronic kidney disease (CKD) is a common and serious problem that adversely affects
human health, limits longevity and increases costs to health‐care systems worldwide. Its …

Transporters in proximal renal tubules contribute to the disposition of numerous drugs.
Furthermore, the molecular mechanisms of tubular secretion have been progressively …

Hyperuricaemia is a common clinical condition that can be defined as a serum uric acid
level> 6.8 mg/dl (404 µmol/l). Gout, a recognized complication of hyperuricaemia, is the most …

Background Dapagliflozin inhibits the sodium‐glucose–linked transporter 2 in the renal
proximal tubule, thereby promoting glycosuria to reduce hyperglycemia in type 2 diabetes …

Uric acid is the product of purine metabolism and its increased levels result in
hyperuricemia. A number of epidemiological reports link hyperuricemia with multiple …

Elevated serum urate concentration is the primary cause of gout. Understanding the
processes that affect serum urate concentration is important for understanding the etiology of …

Exaggerated oxidative stress (OS) is usually considered as a disturbance in regular function
of an organism. The excessive levels of OS mediators may lead to major damage within the …

Multiple interacting checkpoints are involved in the pathophysiology of gout. Hyperuricemia
is the key risk factor for gout and is considered a prerequisite for monosodium urate (MSU) …