Although organic compounds account for more than 99% of currently approved clinical
drugs, the established clinical use of cisplatin in cancer or auranofin in rheumatoid arthritis …

Herein, we report the synthesis of eight new mononuclear and binuclear Co2+, Ni2+, Cu2+,
and Zn2+ methoxy thiosemicarbazone (MTSC) complexes aiming at obtaining …

Topoisomerases, common targets for anti-cancer therapeutics, are crucial enzymes for DNA
replication, transcription, and many other aspects of DNA metabolism. The potential anti …

Three Pd (II) complexes (1–3) containing tridentate chromone-based thiosemicarbazones
(SVSHL1–3) have been investigated as potential anticancer agents. The complexes of the …

Abstract A new unsymmetrical N 2 O 2-tetradentate Schiff-base complex of zinc (II) was
synthesized by the template reaction of pyridoxal-S-methylthiosemicarbazone and 2 …

This paper reports the synthesis and characterization of trans-cinnamaldehyde
thiosemicarbazone (Htcin), cuminaldehyde thiosemicarbazone (Htcum) and their copper …

Cell death is essential for cancer, which can be induced through multiple mechanisms.
Ferroptosis, a newly emerging form of non-apoptotic cell death, involves the generation of …

Although many N-heterocyclic thiosemicarbazone copper complexes have been proposed
as potential anticancer agents, little is known about their intracellular localization in cells. In …

Herein, to develop a multi-target anticancer metal agent and achieve a “1+ 1> 2”
pharmaceutical effect, we rationally designed and synthesized five complexes (C1–C5) by …

New Cu (II), Pd (II) and Pt (II) complexes,(Cu (L)(H2O) 2 (OAc))(1),(Cu (HL)(H2O) 2
(SO4))(2),(Cu (L)(H2O) 2 (NO3))(3),(Cu (L)(H2O) 2 (ClO4))(4),(Cu (L) 2 (H2O) 2)(5),(Pd …