Nicotine withdrawal is associated with deficits in neurocognitive function including sustained
attention, working memory, and response inhibition. Several convergent lines of evidence …

Background There is evidence that substance use disorders and other mental disorders may
have shared biological mechanisms. However, the neurobiological basis of this comorbidity …

Epidemiological and phenomenological studies suggest shared underpinnings between
multiple addictive behaviors. The present genetic association study was conducted as part …

This chapter summarizes genetic factors that contribute to variation in nicotine
pharmacokinetics and nicotine's pharmacological action in the central nervous system …

Drug self-administration procedures in laboratory settings allow us to closely model drug-
taking behavior in real-world settings. This review provides an overview of many of the …

To test the importance of the dopamine D2 receptor (DRD2) region in nicotine dependence,
150 smokers and 228 controls were genotyped for the DRD2 C957T,-141delC and ANKK1 …

Smoking and depression are significant public health problems with multiple etiological
dimensions and outcomes. Although each condition is important by itself, they are important …

Abstract Background Substance-related disorders (SRDs) are a major cause of morbidity
and mortality worldwide. Family, twin, and adoption studies have demonstrated the …

Although a number of studies have analyzed the relation between the DRD2/ANKK1 gene
Taq1A polymorphism and smoking cessation, the results remain controversial. The primary …

Background The co-occurrence of smoking behaviors and major depressive disorder (MDD)
has been widely documented in populations. However, the underlying mechanism of this …