Single-cell RNA sequencing in pancreatic cancer
The application of single-cell RNA sequencing platforms has generated notable insights into
the heterogeneity underlying pancreatic ductal adenocarcinoma (PDAC), encompassing …
the heterogeneity underlying pancreatic ductal adenocarcinoma (PDAC), encompassing …
Cell lineage infidelity in PDAC progression and therapy resistance
A Malinova, L Veghini, FX Real… - Frontiers in Cell and …, 2021 - frontiersin.org
Infidelity to cell fate occurs when differentiated cells lose their original identity and either
revert to a more multipotent state or transdifferentiate into a different cell type, either within …
revert to a more multipotent state or transdifferentiate into a different cell type, either within …
Elucidation of tumor-stromal heterogeneity and the ligand-receptor interactome by single-cell transcriptomics in real-world pancreatic cancer biopsies
Purpose: Precision medicine approaches in pancreatic ductal adenocarcinoma (PDAC) are
imperative for improving disease outcomes. With molecular subtypes of PDAC gaining …
imperative for improving disease outcomes. With molecular subtypes of PDAC gaining …
Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy
TG Krieger, S Le Blanc, J Jabs, FW Ten… - Nature …, 2021 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is projected to be the second leading cause of
cancer mortality by 2030. Bulk transcriptomic analyses have distinguished 'classical'from …
cancer mortality by 2030. Bulk transcriptomic analyses have distinguished 'classical'from …
Establishment of a reference single-cell RNA sequencing dataset for human pancreatic adenocarcinoma
R Chijimatsu, S Kobayashi, Y Takeda, M Kitakaze… - IScience, 2022 - cell.com
Single-cell RNA sequencing (scRNAseq) has been used to assess the intra-tumor
heterogeneity and microenvironment of pancreatic ductal adenocarcinoma (PDAC) …
heterogeneity and microenvironment of pancreatic ductal adenocarcinoma (PDAC) …
Deconstructing pancreatic cancer using next generation-omic technologies–from discovery to knowledge-guided platforms for better patient management
D Schreyer, JP Neoptolemos, ST Barry… - Frontiers in Cell and …, 2022 - frontiersin.org
Comprehensive molecular landscaping studies reveal a potentially brighter future for
pancreatic ductal adenocarcinoma (PDAC) patients. Blood-borne biomarkers obtained from …
pancreatic ductal adenocarcinoma (PDAC) patients. Blood-borne biomarkers obtained from …
Novel role for ST6Gal1 sialyltransferase as a tumor driver in pancreatic ductal adenocarcinoma
NU Bhalerao - 2023 - search.proquest.com
ST6Gal1 sialyltransferase adds negatively charged sialic acid in an α2, 6 linkage to N-
glycans on glycoproteins bound for the cell surface/secretion thus altering receptor structure …
glycans on glycoproteins bound for the cell surface/secretion thus altering receptor structure …