The unfolded protein response (UPR) is activated upon the accumulation of misfolded
proteins in the endoplasmic reticulum (ER) that are sensed by the binding immunoglobulin …

In the last decade, the endoplasmic reticulum (ER) has emerged as a central organelle
regulating the core mitochondrial apoptosis pathway. At the ER membrane, a variety of …

Background The regulatory mechanisms involved in mitochondrial quality control (MQC)
dysfunction during septic cardiomyopathy (SCM) remain incompletely characterized …

The endoplasmic reticulum (ER), mitochondria and lysosomes are physically and/or
functionally linked, establishing close contact sites between these organelles. As a …

Endoplasmic reticulum (ER) stress is a hallmark feature of secretory cells and many
diseases, including cancer, neurodegeneration, and diabetes. Adaptation to protein-folding …

Mitochondria adapt to different energetic demands reshaping their proteome. Mitochondrial
proteases are emerging as key regulators of these adaptive processes. Here, we use a …

Programmed cell death (PCD) is a genetically controlled process described both in
eukaryotic and prokaryotic organisms. Even if it is clear that PCD occurs in plants, in …

Inside cells, the endoplasmic reticulum (ER) forms the largest Ca 2+ store. Ca 2+ is actively
pumped by the SERCA pumps in the ER, where intraluminal Ca 2+-binding proteins enable …

Cell-death and-survival decisions are critically controlled by intracellular Ca 2+ homeostasis
and dynamics at the level of the endoplasmic reticulum (ER). Inositol 1, 4, 5-trisphosphate …

Calcium is a versatile and dynamic 2nd messenger that is essential for the survival of all
higher organisms. In cells that undergo activation or excitation, calcium is released from the …