IGF-I: a key growth factor that regulates neurogenesis and synaptogenesis from embryonic to adult stages of the brain
V Nieto-Estévez, Ç Defterali… - Frontiers in …, 2016 - frontiersin.org
The generation of neurons in the adult mammalian brain requires the activation of quiescent
neural stem cells (NSCs). This activation and the sequential steps of neuron formation from …
neural stem cells (NSCs). This activation and the sequential steps of neuron formation from …
Insulin receptor in the brain: Mechanisms of activation and the role in the CNS pathology and treatment
I Pomytkin, JP Costa‐Nunes, V Kasatkin… - CNS neuroscience & …, 2018 - Wiley Online Library
While the insulin receptor (IR) was found in the CNS decades ago, the brain was long
considered to be an insulin‐insensitive organ. This view is currently revisited, given …
considered to be an insulin‐insensitive organ. This view is currently revisited, given …
Tet1 is critical for neuronal activity-regulated gene expression and memory extinction
The ten-eleven translocation (Tet) family of methylcytosine dioxygenases catalyze oxidation
of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and promote DNA …
of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and promote DNA …
[HTML][HTML] Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories
Traumatic events generate some of the most enduring forms of memories. Despite the
elevated lifetime prevalence of anxiety disorders, effective strategies to attenuate long-term …
elevated lifetime prevalence of anxiety disorders, effective strategies to attenuate long-term …
Local autocrine plasticity signaling in single dendritic spines by insulin-like growth factors
The insulin superfamily of peptides is essential for homeostasis as well as neuronal
plasticity, learning, and memory. Here, we show that insulin-like growth factors 1 and 2 (IGF1 …
plasticity, learning, and memory. Here, we show that insulin-like growth factors 1 and 2 (IGF1 …
Elevated paternal glucocorticoid exposure alters the small noncoding RNA profile in sperm and modifies anxiety and depressive phenotypes in the offspring
Recent studies have suggested that physiological and behavioral traits may be
transgenerationally inherited through the paternal lineage, possibly via non-genomic signals …
transgenerationally inherited through the paternal lineage, possibly via non-genomic signals …
GluT4: A central player in hippocampal memory and brain insulin resistance
EC McNay, J Pearson-Leary - Experimental neurology, 2020 - Elsevier
Insulin is now well-established as playing multiple roles within the brain, and specifically as
regulating hippocampal cognitive processes and metabolism. Impairments to insulin …
regulating hippocampal cognitive processes and metabolism. Impairments to insulin …
IGF2 in memory, neurodevelopmental disorders, and neurodegenerative diseases
CM Alberini - Trends in neurosciences, 2023 - cell.com
Insulin-like growth factor 2 (IGF2) emerged as a critical mechanism of synaptic plasticity and
learning and memory. Deficits in IGF2 in the brain, serum, or cerebrospinal fluid (CSF) are …
learning and memory. Deficits in IGF2 in the brain, serum, or cerebrospinal fluid (CSF) are …
Insulin and IGF receptor signalling in neural-stem-cell homeostasis
AN Ziegler, SW Levison, TL Wood - Nature Reviews Endocrinology, 2015 - nature.com
Neural stem cells (NSCs) are found in two regions in the adult brain: the subgranular zone
(SGZ) in the hippocampal dentate gyrus and the subventricular zone (SVZ) adjacent to the …
(SGZ) in the hippocampal dentate gyrus and the subventricular zone (SVZ) adjacent to the …
Gene expression profiling of neural stem cells and their neuronal progeny reveals IGF2 as a regulator of adult hippocampal neurogenesis
Neural stem cells (NSCs) generate neurons throughout life in the hippocampal dentate
gyrus (DG). How gene expression signatures differ among NSCs and immature neurons …
gyrus (DG). How gene expression signatures differ among NSCs and immature neurons …