Distilling biologically meaningful information from cancer genome sequencing data requires comprehensive identification of somatic alterations using rigorous computational methods …
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Here, using whole-genome, exome and transcriptome sequencing of 2,754 childhood patients with ALL …
M Chan-Seng-Yue, JC Kim, GW Wilson, K Ng… - Nature …, 2020 - nature.com
Pancreatic adenocarcinoma presents as a spectrum of a highly aggressive disease in patients. The basis of this disease heterogeneity has proved difficult to resolve due to poor …
Pancreatic cancer is the most lethal common solid malignancy. Systemic therapies are often ineffective, and predictive biomarkers to guide treatment are urgently needed. We generated …
S Newman, J Nakitandwe, CA Kesserwan, EM Azzato… - Cancer discovery, 2021 - AACR
Genomic studies of pediatric cancer have primarily focused on specific tumor types or high- risk disease. Here, we used a three-platform sequencing approach, including whole …
S Kosugi, Y Momozawa, X Liu, C Terao, M Kubo… - Genome biology, 2019 - Springer
Abstract Background Structural variations (SVs) or copy number variations (CNVs) greatly impact the functions of the genes encoded in the genome and are responsible for diverse …
Cholangiocarcinoma (CCA) is a hepatobiliary malignancy exhibiting high incidence in countries with endemic liver-fluke infection. We analyzed 489 CCAs from 10 countries …
M Umeda, J Ma, T Westover, Y Ni, G Song… - Nature Genetics, 2024 - nature.com
Recent studies on pediatric acute myeloid leukemia (pAML) have revealed pediatric-specific driver alterations, many of which are underrepresented in the current classification schemas …
In recent years, many software packages for identifying structural variants (SVs) using whole- genome sequencing data have been released. When published, a new method is commonly …