Immunotherapy has emerged as a viable clinical strategy to harness endogenous antitumor
T-cell immunity. Lenalidomide is an oral immunomodulatory drug that repairs antitumor T …

Targeted Protein Degradation (TPD) represented by Proteolysis-Targeting Chimeras
(PROTAC) is the frontier field in the research and development of antitumor therapy, in …

Immunomodulatory drugs (IMiDs) have potent anti-tumor activities in multiple myeloma (MM)
and are able to enhance the cytotoxic function of natural killer (NK) cells, important effectors …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy, and
T-ALL patients are prone to early disease relapse and suffer from poor outcomes. The …

Among osteopontin splice variants (OPN-SV), the expression profile of osteopontin-4
(OPN4) and osteopontin-5 (OPN5) has not been addressed in distinct cancer types. We …

Introduction: A deeper understanding of chronic lymphocytic leukemia (CLL) biology has led
to the identification of new promising therapeutic targets. Different classes of molecules are …

Ikaros, a zinc finger transcription factor, is an important regulator of the hematopoietic
system. Several studies have suggested the role of Ikaros in the development, maturation …

TO THE EDITOR: The simultaneous development of JAK2 mutation-related essential
thrombocythemia and B-cell CLL is very rare in the context of contemporary myeloid and …

Background Autoimmune diseases are syndromes characterized by an immune response
against self-antigens. They are complex pathologies associated with a variety of genetic …

La inflamación crónica se ha asociado con el desarrollo de gran número de enfermedades,
tales como cáncer y enfermedades autoinmunes. Uno de los principales reguladores de la …