The common mutation BRAFV600 in primary melanomas activates the mitogen-activated
protein kinase/extracellular-signal-regulated kinase (MAPK/ERK) pathway and the …

Simple Summary Cancer is a multifactorial disease characterized by excessive cell
proliferation in a specific organ. The most common treatments include chemotherapy …

Ras proteins are essential mediators of a multitude of cellular processes, and its
deregulation is frequently associated with cancer appearance, progression, and metastasis …

Cholesterol is an amphipathic sterol molecule that is vital for maintaining normal
physiological homeostasis. It is a relatively complicated molecule with 27 carbons whose …

Celastrol has been reported to possess anticancer effects in various cancers; however, the
precise mechanism underlying ROS-mediated mitochondria-dependent apoptotic cell death …

Cancer stem cells (CSCs) are subpopulation of cells which have been demonstrated in a
variety of cancer models and involved in cancer initiation, progression, and development …

Mesenchymal stem cells (MSCs), one of the most common types of stem cells, are involved
in the modulation of the tumor microenvironment (TME). With the advancement of …

Simple Summary Pediatric high-grade glioma (pHGG) has a dismal prognosis in which the
younger the patient, the more restricted the treatments are, in regard to the incurred risks …

Elevated oxidative stress in cancer cells contributes to hyperactive proliferation and
enhanced survival, which can be exploited using agents that increase reactive oxygen …

The plant kingdom is a source of important therapeutic agents. Therefore, in this review, we
focus on natural compounds that exhibit efficient anti-inflammatory activity via modulation …