J Barratt, J Feehally, AC Smith - Seminars in nephrology, 2004 - Elsevier
In IgA nephropathy (IgAN), there is dysregulation of the IgA response to a wide range of antigens. The dysregulation promotes synthesis of polymeric IgA1 (pIgA1) with …
CS Kaetzel, JK Robinson… - Proceedings of the …, 1991 - National Acad Sciences
The polymeric immunoglobulin receptor (pIgR) on mucosal epithelial cells binds dimeric IgA (dIgA) on the basolateral surface and mediates transport of dIgA to the apical surface. Using …
M Tomana, K Matousovic, BA Julian, J Radl… - Kidney international, 1997 - Elsevier
Galactose-deficient IgA1 in sera of IgA nephropathy patients is present in complexes with IgG. IgA1 proteins from sera of patients with IgA nephropathy (IgAN) are galactosylated to a …
J Mestecky, M Tomana… - Contributions to …, 1993 - books.google.com
Elevated plasma levels of IgA1, IgA1-rheumatoid factor (RF), and IgA1-containing immune complexes (IgA1-IC) have been detected in patients with a broad spectrum of diseases …
Human immunoglobulin (Ig) A exists in blood as two isotypes, IgA1 and IgA2, with IgA2 present as three allotypes: IgA2m (1), IgA2m (2), and IgA2m (n). We now demonstrate that …
M Sato, O Hotta, S Tomioka, I Horigome… - Nephron Clinical …, 2003 - karger.com
Background: Elevated serum creatinine is associated with poor outcome in IgA nephropathy (IgAN). The efficacy and limitations of corticosteroids in advanced IgAN (Cr≧ 1.5 mg/dl) …
J Barratt, AC Smith, K Molyneux, J Feehally - Seminars in …, 2007 - Springer
The defining hallmark of IgA nephropathy (IgAN) is deposition of polymeric IgA1 in the glomerular mesangium accompanied by a mesangial proliferative glomerulonephritis. The …
Discussion DR. STEVEN N. EMANCIPATOR (Pathologist, University Hos-pitals of Cleveland, and Associate Professor of Pathology, Case Western Reserve University School …
T Imasawa, R Nagasawa, Y Utsunomiya… - Kidney international, 1999 - Elsevier
Bone marrow transplantation attenuates murine IgA nephropathy: Role of a stem cell disorder. Background The pathogenesis of IgA nephropathy is still obscure. The aim of this …