Epstein–Barr virus and multiple sclerosis

SS Soldan, PM Lieberman - Nature Reviews Microbiology, 2023 - nature.com
Epstein–Barr virus (EBV) is a ubiquitous human lymphotropic herpesvirus with a well-
established causal role in several cancers. Recent studies have provided compelling …

Guidelines for the use of flow cytometry and cell sorting in immunological studies

A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2021 - Wiley Online Library
The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

Cellular responses to viral infection in humans: lessons from Epstein-Barr virus

AD Hislop, GS Taylor, D Sauce… - Annu. Rev. Immunol …, 2007 - annualreviews.org
Epstein-Barr virus (EBV) provides a useful model to study cellular immunity to a genetically
stable, persistent human virus. Different sets of proteins expressed during EBV's lytic and …

EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-γ and IL-2

JD Lünemann, I Jelčić, S Roberts… - The Journal of …, 2008 - rupress.org
Symptomatic primary Epstein-Barr virus (EBV) infection and elevated humoral immune
responses to EBV are associated with an increased risk of developing multiple sclerosis …

Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation

JP Casazza, MR Betts, DA Price, ML Precopio… - The Journal of …, 2006 - rupress.org
The role of CD4+ T cells in the control of persistent viral infections beyond the provision of
cognate help remains unclear. We used polychromatic flow cytometry to evaluate the …

Combining antivirals and immunomodulators to fight COVID-19

V Feuillet, B Canard, A Trautmann - Trends in immunology, 2021 - cell.com
The majority of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected
individuals remain paucisymptomatic, contrasting with a minority of infected individuals in …

The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression

PK Chattopadhyay, MR Betts, DA Price… - Journal of Leucocyte …, 2009 - academic.oup.com
Cytolytic enzymes (CEs) are critical mediators of anti-viral and-tumor immunity; however, as
a number of molecules belong to this enzyme family, our understanding of CEs remains …

Rapidly generated multivirus-specific cytotoxic T lymphocytes for the prophylaxis and treatment of viral infections

U Gerdemann, JM Keirnan, UL Katari, R Yanagisawa… - Molecular therapy, 2012 - cell.com
Severe and fatal viral infections remain common after hematopoietic stem cell
transplantation. Adoptive transfer of cytotoxic T lymphocytes (CTLs) specific for Epstein–Barr …

Differential Immunogenicity of Epstein-Barr Virus Latent-Cycle Proteins for Human CD4+ T-Helper 1 Responses

ANN Leen, P Meij, I Redchenko, J Middeldorp… - Journal of …, 2001 - Am Soc Microbiol
ABSTRACT Human CD4+ T-helper 1 cell responses to Epstein-Barr virus (EBV) infection
are likely to be important in the maintenance of virus-specific CD8+ memory and/or as …

Increased frequency and broadened specificity of latent EBV nuclear antigen-1-specific T cells in multiple sclerosis

JD Lünemann, N Edwards, PA Muraro, S Hayashi… - Brain, 2006 - academic.oup.com
Epidemiological studies consistently demonstrate that patients with multiple sclerosis are
almost universally infected with Epstein–Barr virus (EBV) and that the risk of developing the …