Clinical management of human immunodeficiency virus type-1 (HIV-1) infection may be
negatively impacted by either acquired or transmitted drug resistance. Here, we aim to …

The HIV-1 infection epidemic remains a global health problem. Current antiretroviral
treatments are effective in controlling the progression of a severe infection. However, the …

Transmitted HIV drug resistance in Bulgaria was first reported in 2015 using data from 1988–
2011. We determined the prevalence of surveillance drug resistance mutations (SDRMs) …

To evaluate the prevalence of transmitted drug resistance (TDR) to nucleoside and
nonnucleoside reverse transcriptase inhibitors (NRTI, NNRTI), protease inhibitors (PI), and …

In recent years, especially as a result of war in Ukraine, enormous movements of migration
to Poland from eastern European countries have been reported, including people living with …

Integrase inhibitors (INIs) are a potent option for HIV treatment. Limited data exist on INI
resistance in West Africa, particularly in children living with HIV/AIDS. We determined the …

The growing emergence of non-nucleoside reverse transcriptase inhibitor (NNRTI) HIV drug
resistance in sub-Saharan Africa (SSA) led to the World Health Organization (WHO) …

Mathematical models have evolved to capture epidemiological and infectious disease data
and complex relationships between the disease, host, and environment. Infectious disease …

With our continuous endeavors in seeking potent anti-HIV-1 agents, we reported here the
discovery, biological characterization, and druggability evaluation of a class of …

传播性耐药(transmitted drug resistance, TDR) 指HIV 耐药毒株的感染, 在没有抗逆转录病毒(
antiretroviral, ARV) 药物暴露史的患者中检出耐药, 将影响一线抗病毒治疗及暴露前后预防的 …