The eukaryotic ubiquitin family encompasses nearly 20 proteins that are involved in the
posttranslational modification of various macromolecules. The ubiquitin-like proteins (UBLs) …

Splicing of the precursor messenger RNA, involving intron removal and exon ligation, is
mediated by the spliceosome. Together with biochemical and genetic investigations of the …

In honey bees (Apis mellifera), the development of a larva into either a queen or worker
depends on differential feeding with royal jelly and involves epigenomic modifications by …

Recent studies have propagated the model that the mitochondrial unfolded protein response
(UPRmt) is causal for lifespan extension from inhibition of the electron transport chain (ETC) …

The pre-catalytic spliceosome (B complex) is preceded by its precursor spliceosome (pre-B
complex) and followed by the activated spliceosome (Bact complex). The pre-B-to-B and B …

As we near a complete understanding of plant transcriptomes and their corresponding
proteomes, a remaining frontier in plant biology will be the in-depth definition of the …

The functional consequences of alternative splicing on altering the transcription rate have
been the subject of intensive study in mammalian cells but less is known about effects of …

The B complex is a key intermediate stage of spliceosome assembly. To improve the
structural resolution of monomeric, human spliceosomal B (hB) complexes and thereby …

Exosomes, a type of small extracellular vesicles (sEVs), are secreted membrane vesicles
that are derived from various cell types, including cancer cells, mesenchymal stem cells, and …

Saccharomyces cerevisiae has been used as a model system to investigate the
mechanisms of pre-mRNA splicing but only a few examples of alternative splice site usage …