Fat tissue, frequently the largest organ in humans, is at the nexus of mechanisms involved in
longevity and age‐related metabolic dysfunction. Fat distribution and function change …

Adipose tissue constitutes an extremely active endocrine organ with a network of signaling
pathways enabling the organism to adapt to a wide range of different metabolic challenges …

Obesity alters adipose tissue metabolic and endocrine function and leads to an increased
release of fatty acids, hormones, and proinflammatory molecules that contribute to obesity …

Clinical and epidemiological studies support a connection between obesity and thrombosis,
involving elevated expression of the prothrombotic molecules plasminogen activator …

Adipose tissue resident macrophages have important roles in the maintenance of tissue
homeostasis and regulate insulin sensitivity for example by secreting pro-inflammatory or …

Recent discoveries, notably of the hormones leptin and adiponectin, have revised the notion
that adipocytes are simply a storage depot for body energy. Instead, adipocytes are also …

The traditional role attributed to white adipose tissue is energy storage, fatty acids being
released when fuel is required. The metabolic role of white fat is, however, complex. For …

Substantial evidence shows that neoplastic and nonneoplastic tissue growth is dependent
on angiogenesis. Neovascularization and adipogenesis are temporally and spatially …

The adverse long‐term effects of diabetes mellitus have been well described and involve
many organ systems. While diabetes management has largely focused on control of …

We study the satisfiability of randomly generated formulas formed by M clauses of exactly K
literals over N Boolean variables. For a given value of N the problem is known to be most …