The ongoing obesity pandemic generates a constant need to develop new therapeutic
strategies to restore the energy balance. Therefore, the concept of activating brown adipose …

Low plasma testosterone (T) levels correlated with metabolic syndrome, cardiovascular
diseases, and increased mortality risk. T exerts a significant effect on the regulation of …

Skeletal muscle and adipose tissue are the two largest organs in the body. Skeletal muscle
is an effector organ, and adipose tissue is an organ that stores energy; in addition, they are …

Aims Exercise-stimulated myokine secretion into circulation may be related with browning in
white adipose tissue (WAT), representing a positive metabolic effect on whole-body fat …

Interleukin (IL)-6 has been studied since its discovery for its role in health and diseases. It is
one of the most important pro-inflammatory cytokines. IL-6 was reported as an exacerbating …

Obesity and type 2 diabetes account for a considerable proportion of the global burden of
age-related metabolic diseases. In age-related metabolic diseases, tissue crosstalk and …

Duchenne muscular dystrophy (DMD), an incurable and a progressive muscle wasting
disease, is caused by the absence of dystrophin protein, leading to recurrent muscle fiber …

Obesity is a global epidemic, accompanied by increased risk of type 2 diabetes and
cardiovascular disease. Adipose tissue hypertrophy is associated with adipose tissue …

Growing old is patently among the most prominent risk factors for lifestyle-related diseases
and deterioration in physical performance. Aging in particular affects mitochondrial …

An acute bout of exercise imposes a major challenge on whole-body metabolism and
metabolic adjustments are needed in multiple tissues during recovery to reestablish …