Diffusion and Flux Improvement of Drugs through Complexation
Improving the solubility and permeability of drugs via cocrystallization is an important theme
in crystal engineering with practical applications for the discovery and development of high …
in crystal engineering with practical applications for the discovery and development of high …
An outlook on permeability escalation through cocrystallization for developing pharmaceuticals with improved biopharmaceutical properties
Permeability of any pharmaceutical is critically significant for its biopharmaceutical profile,
therapeutic activities, and deciding its dosing regimen. Approximately 35% of the marketed …
therapeutic activities, and deciding its dosing regimen. Approximately 35% of the marketed …
A review of coformer utilization in multicomponent crystal formation
Most recently discovered active pharmaceutical molecules and market-approved medicines
are poorly soluble in water, resulting in limited drug bioavailability and therapeutic …
are poorly soluble in water, resulting in limited drug bioavailability and therapeutic …
Cellular assays combined with metabolomics highlight the dual face of phenolics: From high permeability to morphological cell damage
The Caco-2 cellular permeability of phenolic aqueous extracts from blackcurrant press cake
(BC), Norway spruce bark (NS), scots pine bark (SP), and sea buckthorn leaves (SB) was …
(BC), Norway spruce bark (NS), scots pine bark (SP), and sea buckthorn leaves (SB) was …
Multicomponent crystalline solid forms of aripiprazole produced via hot melt extrusion techniques: An exploratory study
A Butreddy, M Almutairi, N Komanduri… - Journal of drug delivery …, 2021 - Elsevier
Multicomponent crystalline solid forms (salts, cocrystals and eutectics) are a promising
means of enhancing the dissolution behavior of poorly soluble drugs. The present study …
means of enhancing the dissolution behavior of poorly soluble drugs. The present study …
Entacapone polymorphs: crystal structures, dissolution, permeability, and stability
MK Bommaka, MK Chaitanya Mannava… - Crystal Growth & …, 2021 - ACS Publications
Entacapone (ETP) is a catechol-O-methyltransferase (COMT) drug used to treat Parkinson's
disease. ETP is available in the marketplace under the brand name Comtan since 2010, and …
disease. ETP is available in the marketplace under the brand name Comtan since 2010, and …
Crystallisation of organic materials from the solution phase: a molecular, synthonic and crystallographic perspective
The fundamental crystal science underpinning the industrial crystallisation of organic
materials is reviewed from molecular, intermolecular (synthonic) and crystallographic …
materials is reviewed from molecular, intermolecular (synthonic) and crystallographic …
Tuning Caco-2 permeability by cocrystallization: Insights from molecular dynamics simulation
Emerging evidence suggests that intestinal permeability can be potentially enhanced
through cocrystallization. However, a mechanism for this effect remains to be established. In …
through cocrystallization. However, a mechanism for this effect remains to be established. In …
Nanocellulose-based nanogels for sustained drug delivery: Preparation, characterization and in vitro evaluation
Polysaccharide-based nanocarriers such as nanogels have recently received considerable
attention in modified drug delivery due to their biocompatibility and biodegradability …
attention in modified drug delivery due to their biocompatibility and biodegradability …
Furosemide/non-steroidal anti-inflammatory drug–drug pharmaceutical solids: Novel opportunities in drug formulation
FJ Acebedo-Martínez, C Alarcón-Payer… - Crystals, 2021 - mdpi.com
The design of drug–drug multicomponent pharmaceutical solids is one the latest drug
development approaches in the pharmaceutical industry. Its purpose is to modulate the …
development approaches in the pharmaceutical industry. Its purpose is to modulate the …