Cerebral dopamine neurotrophic factor protects and repairs dopamine neurons by novel mechanism

P Lindholm, M Saarma - Molecular psychiatry, 2022 - nature.com
Midbrain dopamine neurons deteriorate in Parkinson's disease (PD) that is a progressive
neurodegenerative movement disorder. No cure is available that would stop the …

Trophic activities of endoplasmic reticulum proteins CDNF and MANF

M Jӓntti, BK Harvey - Cell and tissue research, 2020 - Springer
Mesencephalic astrocyte-derived neurotrophic factor (MANF) and cerebral dopamine
neurotrophic factor (CDNF) are endoplasmic reticulum (ER) luminal proteins that confer …

MANF regulates neuronal survival and UPR through its ER-located receptor IRE1α

V Kovaleva, LY Yu, L Ivanova, O Shpironok, J Nam… - Cell Reports, 2023 - cell.com
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum
(ER)-located protein with cytoprotective effects in neurons and pancreatic β cells in vitro and …

The neurotrophic factor MANF regulates autophagy and lysosome function to promote proteostasis in Caenorhabditis elegans

SKB Taylor, JH Hartman, BP Gupta - … of the National Academy of Sciences, 2024 - pnas.org
The conserved mesencephalic astrocyte-derived neurotrophic factor (MANF) is known for
protecting dopaminergic neurons and functioning in various other tissues. Previously, we …

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is highly expressed in mouse tissues with metabolic function

T Danilova, E Galli, E Pakarinen, E Palm… - Frontiers in …, 2019 - frontiersin.org
Mesencephalic astrocyte-derived neurotrophic factor (MANF) and cerebral dopamine
neurotrophic factor (CDNF) form a family of atypical growth factors discovered for their …

UPR Responsive Genes Manf and Xbp1 in Stroke

H Lõhelaid, JE Anttila, HK Liew, KY Tseng… - Frontiers in Cellular …, 2022 - frontiersin.org
Stroke is a devastating medical condition with no treatment to hasten recovery. Its abrupt
nature results in cataclysmic changes in the affected tissues. Resident cells fail to cope with …

CDNF and MANF in the brain dopamine system and their potential as treatment for Parkinson's disease

E Pakarinen, P Lindholm - Frontiers in psychiatry, 2023 - frontiersin.org
Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by
gradual loss of midbrain dopamine neurons, leading to impaired motor function. Preclinical …

[HTML][HTML] Molecular profile of the rat peri-infarct region four days after stroke: study with MANF

J Teppo, A Vaikkinen, V Stratoulias, K Mätlik… - Experimental …, 2020 - Elsevier
The peri-infarct region after ischemic stroke is the anatomical location for many of the
endogenous recovery processes; however,-the molecular events in the peri-infarct region …

Liraglutide protects pancreatic β cells from endoplasmic reticulum stress by upregulating MANF to promote autophagy turnover

J Fu, KM Nchambi, H Wu, X Luo, X An, D Liu - Life sciences, 2020 - Elsevier
Aims This study was conducted to determine the relationship between mesencephalic
astrocyte-derived neurotrophic factor (MANF), autophagy and endoplasmic reticulum (ER) …

MANF ablation causes prolonged activation of the UPR without neurodegeneration in the mouse midbrain dopamine system

E Pakarinen, T Danilova, V Võikar, P Chmielarz… - ENeuro, 2020 - eneuro.org
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum
(ER) localized protein that regulates ER homeostasis and unfolded protein response (UPR) …