Drugs that affect microtubule dynamics, including the taxanes and vinca alkaloids, have
been a mainstay in the treatment of leukemias and solid tumors for decades. New, more …

Simple Summary Microtubules (MTs) are dynamic structures that compose part of the cell
cytoskeleton. They play important roles in various cellular functions, such as intracellular …

All seven lysine residues in ubiquitin contribute to the synthesis of polyubiquitin chains on
protein substrates. Whereas K48-linked chains are well established as mediators of …

The antifreeze glycoprotein-fortified Antarctic notothenioid fishes comprise the predominant
fish suborder in the isolated frigid Southern Ocean. Their ecological success undoubtedly …

Microtubules (MTs) are dynamic polymers that undergo cell cycle and position-sensitive
regulation of polymerization and depolymerization. Although many different factors that …

Chaperonins are large oligomers made up of two superimposed rings, each enclosing a
cavity used for the folding of other proteins. Among the chaperonins, the eukaryotic cytosolic …

The prevailing current view of protein folding is the thermodynamic hypothesis, under which
the native folded conformation of a protein corresponds to the global minimum of Gibbs free …

Synthetic lethal genetic interaction networks define genes that work together to control
essential functions and have been studied extensively in Saccharomyces cerevisiae using …

Chaperonins are ubiquitous chaperones found in Eubacteria, eukaryotic organelles (group
I), Archaea and the eukaryotic cytosol (group II). They all share a common structure and a …

Tubulin, the protein subunit of microtubules (MTs), is an α/β heterodimer. In this chapter, a
hypothesis on the evolution of the tubulin molecule is proposed, based in part on recent …