Background Oxidative liver injury occurring with methotrexate restricts its use in the desired
dose. Therefore, whether or not thiamine and thiamine pyrophosphate, whose antioxidant …

Methotrexate (MTX) is a chemotherapeutic medicine used in the treatment of several types
of cancer and inflammatory diseases. It exhibits several drawbacks especially on highly …

Several studies have well confirmed the contribution of oxidative stress in the pathogenesis
of methotrexate (MTX)-induced damage in the small intestine. Many agents have been tried …

Background Methotrexate (MTX) is an antimetabolite broadly used in treatment of cancer
and autoimmune diseases. MTX-induced hepatotoxicity limits its application. We …

Amethopterin is used as a chemotherapeutic agent, and its antioxidant activity is used to
treat many cancer types. This study aimed to study the ameliorating effect of L-carnitine …

Thymoquinone is the major active component derived from Nigella sativa. Methotrexate is a
folic acid antagonist widely used in clinic. Aim of this study was to investigate the possible …

Ghrelin and melatonin are produced in the central nervous system and in the
gastrointestinal tissues; ghrelin in the stomach, and melatonin-in the liver and in the …

Methotrexate (MTX) treats various diseases but also damages intestinal barrier and leads to
enteritis. Albiflorin (ALB) has a variety of pharmacological effects, including antioxidant, anti …

AIM: To investigate the potential role of oxidative stress and the possible therapeutic effects
of N-acetyl cysteine (NAC), amifostine (AMF) and ascorbic acid (ASC) in methotrexate (MTX) …

Objective: This experimental study was conducted to elucidate the possible
protective/therapeutic effects of quercetin against methotrexate (Mtx)-induced kidney toxicity …