It is now becoming apparent that dynamic changes occur within the interstitium that directly
contribute to adverse myocardial remodeling following myocardial infarction (MI), with …

Hypertensive heart disease (HHD) occurs in patients that clinically have both diastolic and
systolic heart failure and will soon become the most common cause of heart failure. Two key …

Despite current optimal therapeutic regimens, approximately one in four patients diagnosed
with myocardial infarction (MI) will go on to develop congestive heart failure, and heart …

There is increasing evidence that myocardial fibrosis plays a role in the pathogenesis of
diastolic dysfunction in hypertensive heart disease. However, it has been difficult to explore …

Although enhanced cardiac matrix metalloproteinase (MMP)-2 synthesis has been
associated with ventricular remodeling and failure, whether MMP-2 expression is a direct …

Background—Although aldosterone, acting via mineralocorticoid receptors, causes left
ventricular (LV) hypertrophy in experimental models of high-aldosterone hypertension, little …

Matrix metalloproteinases (MMPs) play an important role in the extracellular matrix
remodeling. Experimental and clinical studies have demonstrated that MMP 2 and 9 are …

Background—Continuous-flow left ventricular assist devices (LVAD) are increasingly used
for patients with end-stage heart failure (HF). We analyzed the effects of ventricular …

Matrix metalloproteinases (MMPs), aldosterone, and reactive oxygen species (ROS) are
implicated in myocardial remodeling. Although ROS, cytokines, and neurohormones …

Diabetes mellitus (DM) is associated with an increased incidence of cardiovascular events
and microvascular complications. These complications contribute to the morbidity and …