Stem cells are unique in their ability to self-renew and differentiate into various cell types.
Because of these features, stem cells are key to the formation of organisms and play …

The ectonucleotide pyrophosphatase/phosphodiesterase type 2, more commonly known as
autotaxin (ATX), is an ecto-lysophospholipase D encoded by the human ENNP2 gene. ATX …

About 30% of patients with acute myeloid leukemia (AML) harbour mutations of the receptor
tyrosine kinase FLT3, mostly internal tandem duplications (ITD) and point mutations of the …

Acute myeloid leukemia (AML) is a heterogeneous disease with dismal response warranting
the need for enhancing our understanding of AML biology. One prognostic feature …

In this study we characterized the effects of radiation injury on the expression and function of
the autotaxin (ATX)–LPA 2 GPCR axis. In IEC-6 crypt cells and jejunum enteroids …

Bioactive lipids are fundamental mediators of a number of critical biologic processes such as
inflammation, proliferation, and apoptosis. Rhabdomyosarcoma (RMS) is common in …

Pharmacological mitigation of injuries caused by high-dose ionizing radiation is an unsolved
medical problem. A specific nonlipid agonist of the type 2 G protein coupled receptor for …

Abstract Bioactive phospholipids, including sphingosine-1-phosphate (S1P), ceramide-1-
phosphate (C1P), lysophosphatidylcholine (LPC), and its derivative lysophosphatidic acid …

Bioactive molecules and stem cell-based regenerative engineering is emerging a promising
approach for regenerating tissues. Autotaxin (ATX) is a key enzyme that regulates …

Oxygen signaling is critical for stem cell regulation, and oxidative stress-induced stem cell
apoptosis decreases the efficiency of stem cell therapy. Hypoxia activates O-linked β-N …