Hemolysis is a fundamental feature of sickle cell anemia that contributes to its
pathophysiology and phenotypic variability. Decompartmentalized hemoglobin, arginase 1 …

Glomerular hyperfiltration is a phenomenon that can occur in various clinical conditions
including kidney disease. No single definition of glomerular hyperfiltration has been agreed …

Sickle cell disease (SCD) substantially alters renal structure and function, and causes
various renal syndromes and diseases. Such diverse renal outcomes reflect the uniquely …

Sickle cell syndromes, including sickle cell disease (SCD) and sickle cell trait, are
associated with multiple kidney abnormalities. Young patients with SCD have elevated …

Sickle cell anemia is associated with unusual clinical heterogeneity for a Mendelian
disorder. Fetal hemoglobin concentration and coincident α thalassemia, both which directly …

Importance Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …

Over the past 40 years, public health measures such as universal newborn screening,
penicillin prophylaxis, vaccinations, and hydroxyurea therapy have led to an impressive …

Sickle cell disease is an autosomal recessive, multisystem disorder, characterised by
chronic haemolytic anaemia, painful episodes of vaso-occlusion, progressive organ failure …

Sickle cell disease (SCD) produces many structural and functional abnormalities in the
kidney, including glomerular abnormalities. Albuminuria is the most common manifestation …

Background Hemoglobin sickle cell disease is one of the most frequent
hemoglobinopathies. Surprisingly, few studies have been dedicated to this disease …