Antibiotics in the clinical pipeline in October 2019

MS Butler, DL Paterson - The Journal of antibiotics, 2020 - nature.com
The development of new and effective antibacterial drugs to treat multi-drug resistant (MDR)
bacteria, especially Gram-negative (G− ve) pathogens, is acknowledged as one of the …

Human salmonellosis: a continuous global threat in the farm-to-fork food safety continuum

AD Teklemariam, RR Al-Hindi, RS Albiheyri… - Foods, 2023 - mdpi.com
Salmonella is one of the most common zoonotic foodborne pathogens and a worldwide
public health threat. Salmonella enterica is the most pathogenic among Salmonella species …

From plants to antimicrobials: Natural products against bacterial membranes

F Nourbakhsh, M Lotfalizadeh… - Phytotherapy …, 2022 - Wiley Online Library
Bacterial membrane barrier provides a cytoplasmic environment for organelles of bacteria.
The membrane is composed of lipid compounds containing phosphatide protein and a …

Synthesis and biological evaluation of 1, 2, 4-triazole thioethers as both potential virulence factor inhibitors against plant bacterial diseases and agricultural antiviral …

WB Shao, PY Wang, ZM Fang, JJ Wang… - Journal of Agricultural …, 2021 - ACS Publications
Targeting the virulence factors of phytopathogenic bacteria is an innovative strategy for
alleviating or eliminating the pathogenicity and rapid outbreak of plant microbial diseases …

Antibiotic therapy of plague: a review

F Sebbane, N Lemaître - Biomolecules, 2021 - mdpi.com
Plague—a deadly disease caused by the bacterium Yersinia pestis—is still an international
public health concern. There are three main clinical forms: bubonic plague, septicemic …

Drosophila melanogaster as an organism model for studying cystic fibrosis and its major associated microbial infections

H Touré, JL Herrmann, S Szuplewski… - Infection and …, 2023 - Am Soc Microbiol
Cystic fibrosis (CF) is a human genetic disease caused by mutations in the cystic fibrosis
transmembrane conductance regulator gene that encodes a chloride channel. The most …

The HrpG/HrpX regulon of Xanthomonads—an insight to the complexity of regulation of virulence traits in phytopathogenic bacteria

D Teper, SS Pandey, N Wang - Microorganisms, 2021 - mdpi.com
Bacteria of the genus Xanthomonas cause a wide variety of economically important
diseases in most crops. The virulence of the majority of Xanthomonas spp. is dependent on …

A unified nomenclature for injectisome-type type III secretion systems

S Wagner, A Diepold - Bacterial Type III Protein Secretion Systems, 2020 - Springer
The independent naming of components of injectisome-type type III secretion systems in
different bacterial species has resulted in considerable confusion, impeding accessibility of …

Targeting bacterial pathogenesis by inhibiting virulence-associated Type III and Type IV secretion systems

N Blasey, D Rehrmann, AK Riebisch… - Frontiers in Cellular and …, 2023 - frontiersin.org
Infections caused by Gram-negative pathogens pose a major health burden. Both
respiratory and gastrointestinal infections are commonly associated with these pathogens …

Points of view on the tools for genome/gene editing

CK Chuang, WM Lin - International Journal of Molecular Sciences, 2021 - mdpi.com
Theoretically, a DNA sequence-specific recognition protein that can distinguish a DNA
sequence equal to or more than 16 bp could be unique to mammalian genomes. Long …