Neuro-consequences of the spaceflight environment

SD Mhatre, J Iyer, S Puukila, AM Paul… - Neuroscience & …, 2022 - Elsevier
As human space exploration advances to establish a permanent presence beyond the Low
Earth Orbit (LEO) with NASA's Artemis mission, researchers are striving to understand and …

Impact of spaceflight stressors on behavior and cognition: A molecular, neurochemical, and neurobiological perspective

RI Desai, CL Limoli, CEL Stark, SM Stark - Neuroscience & Biobehavioral …, 2022 - Elsevier
The response of the human body to multiple spaceflight stressors is complex, but mounting
evidence implicate risks to CNS functionality as significant, able to threaten metrics of …

3D biofabrication and space: A 'far-fetched dream'or a 'forthcoming reality'?

N Majumder, S Ghosh - Biotechnology Advances, 2023 - Elsevier
The long duration space missions across the Low Earth Orbit (LEO) often expose the
voyagers to an abrupt zero gravity influence. The severe extraterrestrial cosmic radiation …

Risk of defeats in the central nervous system during deep space missions

VS Kokhan, MI Matveeva, A Mukhametov… - Neuroscience & …, 2016 - Elsevier
Abstract Space flight factors (SFF) significantly affect the operating activity of astronauts
during deep space missions. Gravitational overloads, hypo-magnetic field and ionizing …

Long-term effects of simulated microgravity and/or chronic exposure to low-dose gamma radiation on behavior and blood–brain barrier integrity

JA Bellone, PS Gifford, NC Nishiyama, RE Hartman… - npj …, 2016 - nature.com
Astronauts on lengthy voyages will be exposed to an environment of microgravity and
ionizing radiation that may have adverse effects on physical abilities, mood, and cognitive …

Involvement of cholinergic dysfunction and oxidative damage in the effects of simulated weightlessness on learning and memory in rats

Y Zhang, Q Wang, H Chen, X Liu, K Lv… - BioMed research …, 2018 - Wiley Online Library
The present study aimed to determine how the learning and memory gradually change with
the prolonged hindlimb unloading (HU) treatment in rats. Different HU durations (7 d, 14 d …

Activation of nervous system development genes in bone marrow derived mesenchymal stem cells following spaceflight exposure

M Monticone, Y Liu, N Pujic… - Journal of cellular …, 2010 - Wiley Online Library
Stalled cell division in precursor bone cells and reduced osteoblast function are considered
responsible for the microgravity‐induced bone loss observed during spaceflight. However …

The memory enhancement effect of Kai Xin San on cognitive deficit induced by simulated weightlessness in rats

W Qiong, Z Yong-Liang, L Ying-Hui… - Journal of …, 2016 - Elsevier
Ethnopharmacological relevance It is vital for astronauts to develop effective
countermeasures to prevent their decline of cognitive performance in microgravity to make …

Time-course adaptive changes in hippocampal transcriptome and synaptic function induced by simulated microgravity associated with cognition

R Liang, L Wang, Q Yang, Q Xu, S Sun… - Frontiers in Cellular …, 2023 - frontiersin.org
Introduction The investigation of cognitive function in microgravity, both short-term and long-
term, remains largely descriptive. And the underlying mechanisms of the changes over time …

Evaluation of gene, protein and neurotrophin expression in the brain of mice exposed to space environment for 91 days

D Santucci, F Kawano, T Ohira, M Terada, N Nakai… - PloS one, 2012 - journals.plos.org
Effects of 3-month exposure to microgravity environment on the expression of genes and
proteins in mouse brain were studied. Moreover, responses of neurobiological parameters …