Melatonin analogues potently inhibit MAO-B and protect PC12 cells against oxidative stress

A Elkamhawy, J Woo, NA Gouda, J Kim, H Nada… - Antioxidants, 2021 - mdpi.com
Monoamine oxidase B (MAO-B) metabolizes dopamine and plays an important role in
oxidative stress by altering the redox state of neuronal and glial cells. MAO-B inhibitors are a …

3D printing of customized bioceramics for promoting bone tissue regeneration by regulating sympathetic nerve behavior

Z Su, C Guo, X Gui, L Wu, B Zhang, Y Qin… - Journal of Materials …, 2024 - pubs.rsc.org
Numerous studies have shown that there are multiple neural activities involved in the
process of bone resorption and bone regeneration, and promoting osteogenesis by …

Manipulating cobalt oxide on N-doped aligned electrospun carbon nanofibers towards instant electrochemical detection of dopamine secreted by living cells

Z Yin, Z Ji, BP Bloom, A Jayapalan, M Liu, X Zeng… - Applied Surface …, 2022 - Elsevier
A demand exists for the development of miniaturized biosensors with high sensitivity and a
wide dynamic range for rapid detecting dopamine (DA) levels. In this work, an …

[HTML][HTML] Analytical methodologies for sensing catechol-O-methyltransferase activity and their applications

FY Wang, P Wang, DF Zhao, FJ Gonzalez… - Journal of …, 2021 - Elsevier
Mammalian catechol-O-methyltransferases (COMT) are an important class of conjugative
enzymes, which play a key role in the metabolism and inactivation of catechol …

Highly potent, selective, and competitive indole-based MAO-B inhibitors protect PC12 cells against 6-hydroxydopamine-and rotenone-induced oxidative stress

MH Elsherbeny, J Kim, NA Gouda, L Gotina, J Cho… - Antioxidants, 2021 - mdpi.com
Monoamine oxidase B (MAO-B) is responsible for dopamine metabolism and plays a key
role in oxidative stress by changing the redox state of neuronal and glial cells. To date, no …

Identification of minimum essential therapeutic mixtures from cannabis plant extracts by screening in cell and animal models of Parkinson's disease

MG Morash, J Nixon, LMN Shimoda, H Turner… - Frontiers in …, 2022 - frontiersin.org
Medicinal cannabis has shown promise for the symptomatic treatment of Parkinson's
disease (PD), but patient exposure to whole plant mixtures may be undesirable due to …

A simple microfluidic redox cycling-based device for high-sensitive detection of dopamine released from PC12 cells

M Şen, İ Avcı - Journal of Electroanalytical Chemistry, 2023 - Elsevier
Here, ITO electrodes modified with Au nanoparticles (AuNPs) were used to fabricate a
microfluidic redox cycling-based chip device (AuNPs-MRECD) for highly sensitive and …

[HTML][HTML] Antagonising a novel toxin “T14” in Alzheimer's disease: Comparison of receptor blocker versus antibody effects in vitro

S Hasan, M Ahmed, S Garcia-Ratés… - Biomedicine & …, 2023 - Elsevier
Abstract A 14mer peptide, T14, is a possible signaling molecule driving neurodegeneration.
Its levels are doubled in the Alzheimer brain, but its effects can be blocked at the target …

Alleviating effects of black soybean peptide on oxidative stress injury induced by lead in PC12 cells via Keap1/Nrf2/TXNIP signaling pathway

N Li, L Wen, T Li, H Yang, M Qiao, T Wang, L Song… - Nutrients, 2022 - mdpi.com
Many researchers have found that Pb exposure can cause oxidative stress damage to the
body's tissue. Black soybean peptide (BSP) has a variety of physiological functions …

Pharmacokinetic and permeation studies in rat brain of natural compounds led to investigate eugenol as direct activator of dopamine release in PC12 cells

B Pavan, A Bianchi, G Botti, L Ferraro… - International Journal of …, 2023 - mdpi.com
Eugenol, cinnamaldehyde and D-limonene, the main components of natural essential oils,
are endowed with antioxidant and anti-inflammatory properties which allow them to induce …