Regulation of interferon‐γ during innate and adaptive immune responses
JR Schoenborn, CB Wilson - Advances in immunology, 2007 - Elsevier
Abstract Interferon‐γ (IFN‐γ) is crucial for immunity against intracellular pathogens and for
tumor control. However, aberrant IFN‐γ expression has been associated with a number of …
tumor control. However, aberrant IFN‐γ expression has been associated with a number of …
T-cell subsets (Th1 versus Th2)
S Romagnani - Annals of allergy, asthma & immunology, 2000 - Elsevier
LEARNING OBJECTIVE: To understand the current status of knowledge in the basic field of
polarized specific immune responses mediated by CD4+ T helper (Th) lymphocytes, based …
polarized specific immune responses mediated by CD4+ T helper (Th) lymphocytes, based …
Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus
Rhinoviruses are the major trigger of acute asthma exacerbations and asthmatic subjects
are more susceptible to these infections. To investigate the underlying mechanisms of this …
are more susceptible to these infections. To investigate the underlying mechanisms of this …
Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection
GA Kolumam, S Thomas, LJ Thompson… - The Journal of …, 2005 - rupress.org
T cell expansion and memory formation are generally more effective when elicited by live
organisms than by inactivated vaccines. Elucidation of the underlying mechanisms is …
organisms than by inactivated vaccines. Elucidation of the underlying mechanisms is …
Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th …
R Manetti, P Parronchi, MG Giudizi… - The Journal of …, 1993 - rupress.org
The effects exerted on the in vitro development of antigen-specific T cell lines and T cell
clones by addition or neutralization of interleukin 12 (IL-12) in lymphocyte bulk culture were …
clones by addition or neutralization of interleukin 12 (IL-12) in lymphocyte bulk culture were …
Th1/th2 cells
S Romagnani - Inflammatory bowel diseases, 1999 - Wiley Online Library
A large body of evidence indicates the existence of functionally polarized CD4+ T‐cell
responses based on their profile of cytokine secretion. Type 1 T helper (Th1) cells produce …
responses based on their profile of cytokine secretion. Type 1 T helper (Th1) cells produce …
Th17 cells: new players in asthma pathogenesis
To cite this article: Cosmi L, Liotta F, Maggi E, Romagnani S, Annunziato F. Th17 cells: new
players in asthma pathogenesis. Allergy 2011; 66: 989–998. Abstract CD4+ T effector …
players in asthma pathogenesis. Allergy 2011; 66: 989–998. Abstract CD4+ T effector …
T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis
RC Axtell, BA De Jong, K Boniface, LF Van Der Voort… - Nature medicine, 2010 - nature.com
Abstract Interferon-β (IFN-β) is the major treatment for multiple sclerosis. However, this
treatment is not always effective. Here we have found congruence in outcome between …
treatment is not always effective. Here we have found congruence in outcome between …
Dendritic cell regulation of TH1-TH2 development
M Moser, KM Murphy - Nature immunology, 2000 - nature.com
Understanding the control exerted by cytokines on T helper cell subsets 1 and 2 (TH 1-TH 2)
development has progressed to a fairly satisfying knowledge of intracellular signals and …
development has progressed to a fairly satisfying knowledge of intracellular signals and …
Early development of the gut microbiota and immune health
MP Francino - Pathogens, 2014 - mdpi.com
In recent years, the increase in human microbiome research brought about by the rapidly
evolving “omic” technologies has established that the balance among the microbial groups …
evolving “omic” technologies has established that the balance among the microbial groups …