The hitchhiker's guide to flow chemistry∥

MB Plutschack, B Pieber, K Gilmore… - Chemical …, 2017 - ACS Publications
Flow chemistry involves the use of channels or tubing to conduct a reaction in a continuous
stream rather than in a flask. Flow equipment provides chemists with unique control over …

Flow chemistry remains an opportunity for chemists and chemical engineers

RL Hartman - Current Opinion in Chemical Engineering, 2020 - Elsevier
Highlights•Flow chemistry has evolved from basic laboratory techniques to industrial
practice.•New avenues in reaction chemistry are expanding the molecular toolbox.•Next …

Continuous flow chemistry: where are we now? Recent applications, challenges and limitations

FM Akwi, P Watts - Chemical communications, 2018 - pubs.rsc.org
A general outlook of the changing face of chemical synthesis is provided in this article
through recent applications of continuous flow processing in both industry and academia …

Multigram-scale flow synthesis of the chiral key intermediate of (−)-paroxetine enabled by solvent-free heterogeneous organocatalysis

SB Ötvös, MA Pericàs, CO Kappe - Chemical Science, 2019 - pubs.rsc.org
The catalytic enantioselective synthesis of the chiral key intermediate of the antidepressant
(−)-paroxetine is demonstrated as a continuous flow process on multi-gram scale. The …

A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

G Gambacorta, JS Sharley… - Beilstein journal of …, 2021 - beilstein-journals.org
Due to their intrinsic physical properties, which includes being able to perform as volatile
liquids at room and biological temperatures, fragrance ingredients/intermediates make ideal …

High throughput experimentation using DESI-MS to guide continuous-flow synthesis

BP Loren, HS Ewan, L Avramova, CR Ferreira… - Scientific reports, 2019 - nature.com
We demonstrate the use of accelerated reactions with desorption electrospray ionization
mass spectrometry (DESI-MS) as a tool for predicting the outcome of microfluidic reactions …

[HTML][HTML] Sustainability case studies on the use of continuous manufacturing in pharmaceutical production

MS Kerr, KP Cole - Current Research in Green and Sustainable Chemistry, 2022 - Elsevier
Continuous processing is now commonly used in the manufacturing of fine chemicals
including agrochemicals and pharmaceuticals. Datasets are now available, including some …

Applying green processes and techniques to simplify reaction work-ups

CKZ Andrade, AR Dar - Tetrahedron, 2016 - Elsevier
When planning a reaction, not only its set up but also the way in which the product will be
isolated and purified must be carefully taken into consideration. The work-up of a reaction is …

Flow synthesis of cyclobutanones via [2+ 2] cycloaddition of keteneiminium salts and ethylene gas

C Battilocchio, G Iannucci, S Wang… - Reaction Chemistry & …, 2017 - pubs.rsc.org
A flow chemistry process for the synthesis of 2-substituted cyclobutanones, via [2+ 2]
cycloaddition of keteneiminium salts and ethylene gas, is reported. Our approach uses rapid …

[HTML][HTML] A conceptual investigation for a novel CO2-self-supplied integrated reactor containing ethane thermal cracking and CLC processes

S Zandhaghighi, D Iranshahi, M Shakeri - Results in Engineering, 2024 - Elsevier
In recent years, numerous efforts have been made to enhance ethane thermal cracking
performance, reduce environmental pollution, and save energy. In this study, the …