Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …

Ischemia and reperfusion–elicited tissue injury contributes to morbidity and mortality in a
wide range of pathologies, including myocardial infarction, ischemic stroke, acute kidney …

Strong evidence implicates the complement pathway as an important contributor to amyloid
pathology in Alzheimer's disease (AD); however, the role of complement in tau modulation …

The complement system is an essential element of the innate immune response that
becomes activated upon recognition of molecular patterns associated with microorganisms …

Although new activation and regulatory mechanisms are still being identified, the basic
architecture of the complement system has been known for decades. Two major roles of …

Hepatic ischemia/reperfusion (I/R) injury is a major complication of liver surgery, including
liver resection, liver transplantation, and trauma surgery. Much has been learned about the …

Liver cell death induced by stresses such as ischemia‐reperfusion, cholestasis and drug
toxicity can trigger a sterile inflammatory response with activation of innate immune cells …

The liver is both an immunologically complex and a privileged organ. The innate immune
system is a central player, in which the complement system emerges as a pivotal part of liver …

Bone remodeling is regulated by a coupling of resorption to subsequent formation; however,
the “coupling factor” and underlying mechanism are not fully understood. Here, we found …

Ischemia/reperfusion injury is an inevitable process during liver transplantation and can lead
to a high incidence of early allograft dysfunction and graft failure. The mechanism of hepatic …