Pancreatic ductal adenocarcinomas are distinguished by their robust desmoplasia, or
fibroinflammatory response. Dominated by non-malignant cells, the mutated epithelium must …

Animal models of acute and chronic pancreatitis have been created to examine mechanisms
of pathogenesis, test therapeutic interventions, and study the influence of inflammation on …

Targeting the delivery of therapeutics specifically to diseased tissue enhances their efficacy
and decreases their side effects. Here we show that mesenchymal stromal cells with their …

Existing models of acute pancreatitis have limitations to studying novel therapy. Whereas
some produce mild self-limited pancreatitis, others result in sudden necrotizing injury. The …

In 1900, Adami speculated that a sequence of context‐independent energetic and structural
changes governed the reversion of differentiated cells to a proliferative, regenerative state …

Autodigestion of the pancreas by its own prematurely activated digestive proteases is
thought to be an important event in the onset of acute pancreatitis. The mechanism …

The pancreatic acinar cell produces powerful digestive enzymes packaged in zymogen
granules in the apical pole. Ca2+ signals elicited by acetylcholine or cholecystokinin (CCK) …

Mutations are a critical driver of cancer initiation. While extensive studies have focused on
exposure-induced mutations, few studies have explored the importance of tissue physiology …

Autophagy has recently elicited significant attention as a mechanism that either protects or
promotes cell death, although different autophagy pathways, and the cellular context in …

The transcriptional regulator YAP orchestrates many cellular functions, including tissue
homeostasis, organ growth control, and tumorigenesis. Mechanical stimuli are a key input to …