Amplification and/or overexpression of ERBB2, the gene encoding HER2, can be found in
15–20% of invasive breast cancers and is associated with an aggressive phenotype and …

Simple Summary HER2 intratumoral heterogeneity (ITH) is a well-known phenomenon in
breast cancer, defined as the coexistence of subpopulations of tumor cells with different …

Metastasis is the primary cause of cancer-related deaths, but the natural history, clonal
evolution and impact of treatment are poorly understood. We analyzed whole-exome …

BACKGROUND Recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma
(HNSCC) is generally an incurable disease, with patients experiencing median survival of …

Pathological and genomic profiling have transformed breast cancer care by matching
patients to targeted treatments. However, tumors evolve and evade therapeutic interventions …

Proliferation is a fundamental trait of cancer cells, but its properties and spatial organization
in tumours are poorly characterized. Here we use highly multiplexed tissue imaging to …

Ecological fitness is the ability of individuals in a population to survive and reproduce.
Individuals with increased fitness are better equipped to withstand the selective pressures of …

Highlights•Cancer is a heterogeneous and evolving disease, yet most drugs are
administered to simply give the maximum dose.•Treatment scheduling currently ignores the …

The Wnt/β-catenin pathway, in addition to playing a crucial role in the development of the
mammary gland during embryogenesis and during pregnancy, is one of the most commonly …

Many malignancies display heterogeneous features that support cancer progression.
Emerging high-resolution methods provide a view of heterogeneity that recognizes the …