Adipose-tissue plasticity in health and disease

A Sakers, MK De Siqueira, P Seale, CJ Villanueva - Cell, 2022 - cell.com
Adipose tissue, colloquially known as" fat," is an extraordinarily flexible and heterogeneous
organ. While historically viewed as a passive site for energy storage, we now appreciate that …

Visceral and ectopic fat, atherosclerosis, and cardiometabolic disease: a position statement

IJ Neeland, R Ross, JP Després… - The lancet Diabetes & …, 2019 - thelancet.com
Findings from epidemiological studies over the past 30 years have shown that visceral
adipose tissue, accurately measured by CT or MRI, is an independent risk marker of …

Adipose tissue dysfunction as determinant of obesity-associated metabolic complications

M Longo, F Zatterale, J Naderi, L Parrillo… - International journal of …, 2019 - mdpi.com
Obesity is a critical risk factor for the development of type 2 diabetes (T2D), and its
prevalence is rising worldwide. White adipose tissue (WAT) has a crucial role in regulating …

Obesity I: Overview and molecular and biochemical mechanisms

RH Lustig, D Collier, C Kassotis, TA Roepke… - Biochemical …, 2022 - Elsevier
Obesity is a chronic, relapsing condition characterized by excess body fat. Its prevalence
has increased globally since the 1970s, and the number of obese and overweight people is …

Metabolically healthy obesity: facts and fantasies

GI Smith, B Mittendorfer, S Klein - The Journal of clinical …, 2019 - Am Soc Clin Investig
Although obesity is typically associated with metabolic dysfunction and cardiometabolic
diseases, some people with obesity are protected from many of the adverse metabolic …

Beyond bmi

GA Bray - Nutrients, 2023 - mdpi.com
This review examined the origins of the concept of the BMI in the work of Quetelet in the 19th
century and its subsequent adoption and use in tracking the course of the pandemic of …

The science of obesity management: an endocrine society scientific statement

GA Bray, WE Heisel, A Afshin, MD Jensen… - Endocrine …, 2018 - academic.oup.com
The prevalence of obesity, measured by body mass index, has risen to unacceptable levels
in both men and women in the United States and worldwide with resultant hazardous health …

Cardiovascular and metabolic heterogeneity of obesity: clinical challenges and implications for management

IJ Neeland, P Poirier, JP Després - Circulation, 2018 - Am Heart Assoc
The prevalence of obesity has increased globally over the last 2 decades. Although the body
mass index has been a convenient and simple index of obesity at the population level …

Obesity: a chronic relapsing progressive disease process. A position statement of the World Obesity Federation

GA Bray, KK Kim, JPH Wilding… - Obesity …, 2017 - Wiley Online Library
This paper considers the argument for obesity as a chronic relapsing disease process.
Obesity is viewed from an epidemiological model, with an agent affecting the host and …

Healthy Weight and Obesity Prevention: JACC Health Promotion Series

CJ Lavie, D Laddu, R Arena, FB Ortega… - Journal of the American …, 2018 - jacc.org
Overweight and obesity have reached epidemic levels in the United States and worldwide,
and this has contributed to substantial cardiovascular and other health risks. However …