Age-associated epigenetic changes in mammalian sperm: implications for offspring health and development
V Ashapkin, A Suvorov, JR Pilsner… - Human reproduction …, 2023 - academic.oup.com
BACKGROUND Modern reproductive behavior in most developed countries is characterized
by delayed parenthood. Older gametes are generally less fertile, accumulating and …
by delayed parenthood. Older gametes are generally less fertile, accumulating and …
Mitochondrial functionality in male fertility: from spermatogenesis to fertilization
Mitochondria are structurally and functionally distinct organelles that produce adenosine
triphosphate (ATP) through oxidative phosphorylation (OXPHOS), to provide energy to …
triphosphate (ATP) through oxidative phosphorylation (OXPHOS), to provide energy to …
Transfer learning enables predictions in network biology
Mapping gene networks requires large amounts of transcriptomic data to learn the
connections between genes, which impedes discoveries in settings with limited data …
connections between genes, which impedes discoveries in settings with limited data …
scRNA-seq profiling of human testes reveals the presence of the ACE2 receptor, a target for SARS-CoV-2 infection in spermatogonia, Leydig and Sertoli cells
In December 2019, a novel coronavirus (SARS-CoV-2) was identified in COVID-19 patients
in Wuhan, Hubei Province, China. SARS-CoV-2 shares both high sequence similarity and …
in Wuhan, Hubei Province, China. SARS-CoV-2 shares both high sequence similarity and …
The neonatal and adult human testis defined at the single-cell level
Spermatogenesis has been intensely studied in rodents but remains poorly understood in
humans. Here, we used single-cell RNA sequencing to analyze human testes. Clustering …
humans. Here, we used single-cell RNA sequencing to analyze human testes. Clustering …
[HTML][HTML] The dynamic transcriptional cell atlas of testis development during human puberty
The human testis undergoes dramatic developmental and structural changes during
puberty, including proliferation and maturation of somatic niche cells, and the onset of …
puberty, including proliferation and maturation of somatic niche cells, and the onset of …
[HTML][HTML] Single-cell RNA sequencing of human, macaque, and mouse testes uncovers conserved and divergent features of mammalian spermatogenesis
Spermatogenesis is a highly regulated process that produces sperm to transmit genetic
information to the next generation. Although extensively studied in mice, our current …
information to the next generation. Although extensively studied in mice, our current …
Disrupted spermatogenesis in a metabolic syndrome model: the role of vitamin A metabolism in the gut–testis axis
T Zhang, P Sun, Q Geng, H Fan, Y Gong, Y Hu, L Shan… - Gut, 2022 - gut.bmj.com
Objective Effects of the diet-induced gut microbiota dysbiosis reach far beyond the gut. We
aim to uncover the direct evidence involving the gut–testis axis in the aetiology of impaired …
aim to uncover the direct evidence involving the gut–testis axis in the aetiology of impaired …
Single-cell multi-omics sequencing of human spermatogenesis reveals a DNA demethylation event associated with male meiotic recombination
Y Huang, L Li, G An, X Yang, M Cui, X Song, J Lin… - Nature Cell …, 2023 - nature.com
Human spermatogenesis is a highly ordered process; however, the roles of DNA
methylation and chromatin accessibility in this process remain largely unknown. Here by …
methylation and chromatin accessibility in this process remain largely unknown. Here by …
Deep generative modeling of transcriptional dynamics for RNA velocity analysis in single cells
RNA velocity has been rapidly adopted to guide interpretation of transcriptional dynamics in
snapshot single-cell data; however, current approaches for estimating RNA velocity lack …
snapshot single-cell data; however, current approaches for estimating RNA velocity lack …