Antibody glycosylation is a common post-translational modification and has a critical role in
antibody effector function. The use of glycoengineering to produce antibodies with specific …

Through process transfer and optimization for increased antibody production to 3 g/L for a
GS‐CHO cell line, an undesirable drop in antibody Fc galactosylation was observed. Uridine …

Controlled feeding of glucose has been employed previously to enhance the productivity of
recombinant glycoproteins but there is a concern that low concentrations of glucose could …

The application of multiplexed isobaric tandem mass tag (TMT) labeling and an LTQ
Orbitrap XL ETD (electron transfer dissociation) hybrid mass spectrometer as a direct …

Plants are attractive hosts for the production of recombinant proteins. However, their inability
to process authentic human N-glycan structures imposes a major limitation on their use as …

SFM (serum‐free medium) is preferred to media containing animal‐derived components
when culturing mammalian cells for the production of therapeutic recombinant proteins and …

There is increasing evidence supporting a role for antibodies in protection against
tuberculosis (TB), with functional antibodies being described in the latent state of TB …

N-glycosylation is one of the most crucial parameters affecting the biological activity of
therapeutic monoclonal antibodies (mAbs), and should therefore be closely monitored and …

With the trend towards the generation and production of increasing numbers of complex
biopharmaceutical (protein based) products, there is an increased need and requirement to …

The necessity to perform serum-free cultures to produce recombinant glycoproteins
generally requires an adaptation procedure of the cell line to new environmental conditions …