Cholangiocarcinoma—controversies and challenges

T Patel - Nature reviews Gastroenterology & hepatology, 2011 - nature.com
Cholangiocarcinomas are a diverse group of tumors that are presumed to originate from the
biliary tract epithelium either within the liver or the biliary tract. These cancers are often …

[HTML][HTML] Molecular mechanisms and clinical applications of miR-22 in regulating malignant progression in human cancer

J Wang, Y Li, M Ding, H Zhang… - … Journal of Oncology, 2017 - spandidos-publications.com
Abstract miRNAs (microRNAs) have been validated to play fateful roles in the occurrence
and development of cancers by post-transcriptionally targeting 3'-untranslated regions of the …

Expression of microRNAs, miR‐21, miR‐31, miR‐122, miR‐145, miR‐146a, miR‐200c, miR‐221, miR‐222, and miR‐223 in patients with hepatocellular carcinoma or …

A Karakatsanis, I Papaconstantinou… - Molecular …, 2013 - Wiley Online Library
MicroRNAs are a class of non‐coding molecules found to regulate a variety of cellular
functions in health and disease. Dysregulation of microRNAs is involved in liver disease …

miR-22 represses cancer progression by inducing cellular senescence

D Xu, F Takeshita, Y Hino, S Fukunaga, Y Kudo… - Journal of Cell …, 2011 - rupress.org
Cellular senescence acts as a barrier to cancer progression, and microRNAs (miRNAs) are
thought to be potential senescence regulators. However, whether senescence-associated …

microRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity

J Zhang, Y Yang, T Yang, Y Liu, A Li, S Fu, M Wu… - British journal of …, 2010 - nature.com
Background: Recently, microRNAs in cancer development have attracted much attention,
but their roles in tumorigenesis are still largely unknown. In this study, a functional role of …

Suppressed miR-424 expression via upregulation of target gene Chk1 contributes to the progression of cervical cancer

J Xu, Y Li, F Wang, X Wang, B Cheng, F Ye, X Xie… - Oncogene, 2013 - nature.com
MicroRNAs (miRNAs) act as important gene regulators in human genomes and their
aberrant expression links to many malignancies. We previously identified a different …

[PDF][PDF] miR‐25 targets TNF‐related apoptosis inducing ligand (TRAIL) death receptor‐4 and promotes apoptosis resistance in cholangiocarcinoma

N Razumilava, SF Bronk, RL Smoot, CD Fingas… - …, 2012 - Wiley Online Library
It has been established that microRNA expression and function contribute to phenotypic
features of malignant cells, including resistance to apoptosis. Although targets and …

MicroRNA regulation of innate immune responses in epithelial cells

R Zhou, SP O'hara, XM Chen - Cellular & molecular immunology, 2011 - nature.com
Mucosal surface epithelial cells are equipped with several defense mechanisms that guard
against pathogens. Recent studies indicate that microRNAs (miRNAs) mediate post …

miR-29b, miR-205 and miR-221 enhance chemosensitivity to gemcitabine in HuH28 human cholangiocarcinoma cells

K Okamoto, K Miyoshi, Y Murawaki - PloS one, 2013 - journals.plos.org
Background and Aims Cholangiocarcinoma (CCA) is highly resistant to chemotherapy,
including gemcitabine (Gem) treatment. MicroRNAs (miRNAs) are endogenous, non-coding …

Serum and tissue markers in hepatocellular carcinoma and cholangiocarcinoma: clinical and prognostic implications

M Berretta, C Cavaliere, L Alessandrini… - …, 2016 - pmc.ncbi.nlm.nih.gov
HCC represents the sixth most common cancer worldwide and the second leading cause of
cancer-related death. Despite the high incidence, treatment options for advanced HCC …