Microneedles: a new generation vaccine delivery system

I Menon, P Bagwe, KB Gomes, L Bajaj, R Gala… - Micromachines, 2021 - mdpi.com
Transdermal vaccination route using biodegradable microneedles is a rapidly progressing
field of research and applications. The fear of painful needles is one of the primary reasons …

[HTML][HTML] Microneedle-based delivery: An overview of current applications and trends

AJ Guillot, AS Cordeiro, RF Donnelly, MC Montesinos… - Pharmaceutics, 2020 - mdpi.com
Microneedle arrays (MNA) are considered as one of the most promising resources to
achieve systemic effects by transdermal delivery of drugs. They are designed as a minimally …

Intranasal vaccination with lipid-conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity

BL Hartwell, MB Melo, P Xiao, AA Lemnios… - Science translational …, 2022 - science.org
To combat the HIV epidemic and emerging threats such as SARS-CoV-2, immunization
strategies are needed that elicit protection at mucosal portals of pathogen entry …

Advances in gene-based vaccine platforms to address the COVID-19 pandemic

D Pushparajah, S Jimenez, S Wong, H Alattas… - Advanced drug delivery …, 2021 - Elsevier
The novel betacoronavirus, SARS-CoV-2 (severe acute respiratory syndrome coronavirus
2), has spread across the globe at an unprecedented rate since its first emergence in Wuhan …

Novel vaccine technologies in veterinary medicine: a herald to human medicine vaccines

V Aida, VC Pliasas, PJ Neasham, JF North… - Frontiers in veterinary …, 2021 - frontiersin.org
The success of inactivated and live-attenuated vaccines has enhanced livestock
productivity, promoted food security, and attenuated the morbidity and mortality of several …

What does plant-based vaccine technology offer to the fight against COVID-19?

S Rosales-Mendoza, VA Márquez-Escobar… - Vaccines, 2020 - mdpi.com
The emergence of new pathogenic viral strains is a constant threat to global health, with the
new coronavirus strain COVID-19 as the latest example. COVID-19, caused by the SARS …

Single-dose mucosal replicon-particle vaccine protects against lethal Nipah virus infection up to 3 days after vaccination

SR Welch, JR Spengler, SC Genzer… - Science …, 2023 - science.org
Nipah virus (NiV) causes a highly lethal disease in humans who present with acute
respiratory or neurological signs. No vaccines against NiV have been approved to date …

Towards the future exploration of mucosal mRNA vaccines against emerging viral diseases; lessons from existing next-generation mucosal vaccine strategies

SA Hameed, S Paul, GKY Dellosa, D Jaraquemada… - npj Vaccines, 2022 - nature.com
The mRNA vaccine platform has offered the greatest potential in fighting the COVID-19
pandemic owing to rapid development, effectiveness, and scalability to meet the global …

Oral and intranasal vaccines against SARS‐CoV‐2: Current progress, prospects, advantages, and challenges

S Kar, P Devnath, TB Emran, TE Tallei… - Immunity …, 2022 - Wiley Online Library
Background The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has
caused a deadly pandemic in the 21st century, resulting in many deaths, economic loss, and …

Vaccines, adjuvants and key factors for mucosal immune response

VA Correa, AI Portilho, E De Gaspari - Immunology, 2022 - Wiley Online Library
Vaccines are the most effective tool to control infectious diseases, which provoke significant
morbidity and mortality rates. Most vaccines are administered through the parenteral route …