Urolithins, the rescue of “old” metabolites to understand a “new” concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health …

FA Tomás‐Barberán… - Molecular nutrition & …, 2017 - Wiley Online Library
Urolithins are dibenzo [b, d] pyran‐6‐one derivatives that are produced by the human gut
microbiota from ellagitannins and ellagic acid (EA). These metabolites are much better …

Understanding the molecular mechanisms of the interplay between herbal medicines and gut microbiota

J Xu, HB Chen, SL Li - Medicinal Research Reviews, 2017 - Wiley Online Library
Herbal medicines (HMs) are much appreciated for their significant contribution to human
survival and reproduction by remedial and prophylactic management of diseases. Defining …

Diverse Phytochemicals and Bioactivities in the Ancient Fruit and Modern Functional Food Pomegranate (Punica granatum)

S Wu, L Tian - Molecules, 2017 - mdpi.com
Having served as a symbolic fruit since ancient times, pomegranate (Punica granatum) has
also gained considerable recognition as a functional food in the modern era. A large body of …

Phenolic compounds from nuts: extraction, chemical profiles, and bioactivity

R Bodoira, D Maestri - Journal of agricultural and food chemistry, 2020 - ACS Publications
Nuts contain a vast array of phenolic compounds having important biological properties.
They include substances allocated into the five major groups named phenolic acids …

Metagenomic profiling of the pro-inflammatory gut microbiota in ankylosing spondylitis

C Zhou, H Zhao, X Xiao, R Guo, Q Wang, H Chen… - Journal of …, 2020 - Elsevier
Objective Gut dysbiosis has been reported implicated in ankylosing spondylitis (AS), a
common chronic inflammatory disease mainly affects sacroiliac joints and spine. Utilizing …

Ellagic acid: Pharmacological activities and molecular mechanisms involved in liver protection

WR García-Niño, C Zazueta - Pharmacological Research, 2015 - Elsevier
Traditional drugs or therapies rarely have effects on regression of chronic liver diseases,
which result in many cases from sustained oxidative stress. In recent years, ellagic acid (EA) …

Non-extractable polyphenols produce gut microbiota metabolites that persist in circulation and show anti-inflammatory and free radical-scavenging effects

A González-Sarrías, JC Espín… - Trends in Food Science & …, 2017 - Elsevier
Recent studies demonstrate that fruits are rich in non-extractable polyphenols, macro-
antioxidants, which have been underestimated. These are not absorbed and reach the colon …

Metabolic and microbial modulation of the large intestine ecosystem by non-absorbed diet phenolic compounds: A review

JI Mosele, A Macià, MJ Motilva - Molecules, 2015 - mdpi.com
Phenolic compounds represent a diverse group of phytochemicals whose intake is
associated with a wide spectrum of health benefits. As consequence of their low …

Bioactivity of polyphenols: preventive and adjuvant strategies toward reducing inflammatory bowel diseases—promises, perspectives, and pitfalls

A Kaulmann, T Bohn - Oxidative medicine and cellular …, 2016 - Wiley Online Library
Inflammatory bowel diseases (IBDs) are characterized by autoimmune and inflammation‐
related complications of the large intestine (ulcerative colitis) and additional parts of the …

Urolithins attenuate LPS-induced neuroinflammation in BV2Microglia via MAPK, Akt, and NF-κB signaling pathways

J Xu, C Yuan, G Wang, J Luo, H Ma, L Xu… - Journal of agricultural …, 2018 - ACS Publications
Emerging data suggest that urolithins, gut microbiota metabolites of ellagitannins, contribute
toward multiple health benefits attributed to ellagitannin-rich foods, including walnuts, red …