Isoxazole is an important pharmacophore that is critical for biological activity. The isoxazole
ring ranks 33rd in frequency among the 351 ring systems found in marketed drugs, thus …

This review focuses on providing comprehensive highlights of the recent synthetic pathways
of imidazo [1, 2‐a] pyridines, assisted through transition metal‐catalyzed reactions, multi …

The three-component reactions of enaminones, α-diazo esters/ketones, and t-butyl nitrite
(TBN) for the switchable synthesis of isomeric isoxazoles have been realized. The catalysis …

Ynones are widely used in organic synthesis. Their great success is rooted in their multiple
functional groups. This review focus on advance of ynones in published in the decade 2009 …

An anti-carbonickelative cyclization via reversible alkenylnickel E/Z isomerization of 2-azido
phenyl propargyl alcohols with aryl boronic acids is achieved using Ni (acac) 2 as the …

Isoxazole derivatives are aromatic five-membered ring heterocyclic compounds with one
oxygen atom and one nitrogen atom at adjacent positions. These compounds have a broad …

Over the past few decades, the development of versatile methodologies to employ azides as
aminating agents for the formation of nitrogen-containing compounds has attracted …

A four-component strategy for the synthesis of the isoxazole skeleton is developed. The
approach achieves the synthesis of perfluoroalkyl isoxazoles by using simple perfluoroalkyl …

A regio-and stereoselective thiocyanate addition to ynones is achieved using KSCN in
AcOH at 70° C. The reaction is extendable to ynals, ynesulfones, ynoic acids and ynoates …

This review summarizes the main directions and recent trends in the synthesis of isoxazoles,
and also provides examples of the use of isoxazoles as biologically active compounds in …