Flavonoids and their anti-diabetic effects: Cellular mechanisms and effects to improve blood sugar levels

RK Al-Ishaq, M Abotaleb, P Kubatka, K Kajo… - Biomolecules, 2019 - mdpi.com
Diabetes mellitus (DM) is a prevailing global health metabolic disorder, with an alarming
incidence rate and a huge burden on health care providers. DM is characterized by the …

Polyphenols and their benefits: A review

H Rasouli, MH Farzaei… - International Journal of …, 2017 - Taylor & Francis
ABSTRACT “Let food be thy medicine and medicine be thy food” was expressed by
Hippocrates more than 2000 years ago and the health benefits of natural food products have …

Mechanisms of antidiabetic effects of flavonoid rutin

A Ghorbani - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Several lines of evidence suggest that flavonoids that originated from vegetables and
medicinal plants have beneficial effects on diabetes by improving glycemic control, lipid …

Molecular mechanisms of the anti-obesity and anti-diabetic properties of flavonoids

M Kawser Hossain, A Abdal Dayem, J Han… - International journal of …, 2016 - mdpi.com
Obesity and diabetes are the most prevailing health concerns worldwide and their incidence
is increasing at a high rate, resulting in enormous social costs. Obesity is a complex disease …

Dietary polyphenols—Important non-nutrients in the prevention of chronic noncommunicable diseases. A systematic review

W Koch - Nutrients, 2019 - mdpi.com
The improvement of the social and economic conditions of society has eliminated the threat
of death from the majority of infectious diseases. However, the rapid progress of civilization …

Recent advances in understanding the anti-diabetic actions of dietary flavonoids

PVA Babu, D Liu, ER Gilbert - The Journal of nutritional biochemistry, 2013 - Elsevier
Flavonoids are polyphenolic compounds that are abundant in fruits and vegetables, and
increasing evidence demonstrates a positive relationship between consumption of flavonoid …

Antidiabetic potential of flavonoids from traditional Chinese medicine: a review

L Bai, X Li, L He, Y Zheng, H Lu, J Li… - The American journal …, 2019 - World Scientific
Diabetes mellitus (DM) is a group of metabolic disorders in which high blood sugar levels
occur over a prolonged period. Approximately 4% of the global population is affected by DM …

Apigenin and naringenin regulate glucose and lipid metabolism, and ameliorate vascular dysfunction in type 2 diabetic rats

B Ren, W Qin, F Wu, S Wang, C Pan, L Wang… - European journal of …, 2016 - Elsevier
Vascular endothelial dysfunction is regarded as the initial step of vascular complications in
diabetes mellitus. This study investigated the amelioration of apigenin and naringenin in …

Impact of streptozotocin on altering normal glucose homeostasis during insulin testing in diabetic rats compared to normoglycemic rats

NA Qinna, AA Badwan - Drug design, development and therapy, 2015 - Taylor & Francis
Streptozotocin (STZ) is currently the most used diabetogenic agent in testing insulin and
new antidiabetic drugs in animals. Due to the toxic and disruptive nature of STZ on organs …

Review of the protective effects of rutin on the metabolic function as an important dietary flavonoid

H Hosseinzadeh, M Nassiri-Asl - Journal of endocrinological investigation, 2014 - Springer
Background In recent years, flavonoids have been revealed to be helpful in the treatment of
many diseases. Rutin (3, 3′, 4′, 5, 7-pentahydroxyflavone-3-rhamnoglucoside) is an …