Novel and alternative options are being adopted to combat the initiation and progression of
human cancers. One of the approaches is the use of molecules isolated from traditional …

Background: Steroids play an important role in life because they can regulate a variety of
biological processes and have been widely used in medicine namely as antiinflammatory …

A series of novel diosgenin (DSG) and tigogenin (TGG) derivatives with diosgenin or
tigogenin steroid aglycons linked to levulinic and 3, 4–dihydroxycinnamic acids, dipeptides …

Bisindole alkaloids are a source of inspiration for the design and discovery of new-
generation anticancer agents. In this study, we investigated the cytotoxic and …

Steroidal compounds were proven to be efficient drugs against several types of cancer.
Oximes are also chemical structures frequently associated with anticancer activity. The main …

In this work, we report the synthesis of two new azasteroids through the modification of the A
and B rings of diosgenin 1. The 4-azasteroid derivative 12 was prepared in three steps using …

Steroids and their derivatives have been the subject of extensive research among
investigators due to their wide range of pharmacological properties, in which steroidal …

During cancer progression, the unrestricted proliferation of cells is supported by the
impaired cell death response provoked by certain oncogenes. Both autophagy and …

Plants are rich in steroidal and triterpenoid saponins. Diosgenin is an important sapogenin
obtained from various steroidal saponins and specially from dioscin. It possesses diverse …

This study focused on the fenugreek seed powder extract (FSP-Ex) obtained using four
selected solvents based on polarity differences (acetone, ethanol, hexane, and petroleum …