Hantaviruses (HVs) are rodent-transmitted viruses that can cause hantavirus
cardiopulmonary syndrome (HCPS) in the Americas and hemorrhagic fever with renal …

Hantaviruses are a significant and emerging global public health threat, impacting more
than 200,000 individuals worldwide each year. The single-stranded RNA viruses belong to …

Lethal mutagenesis has emerged as a novel potential therapeutic approach to treat viral
infections. Several studies have demonstrated that increases in the high mutation rates …

Hantavirus-induced diseases are emerging zoonoses with endemic appearances and
frequent outbreaks in different parts of the world. In humans, hantaviral pathology is …

Background: Intravenous ribavirin has been reported to be an effective treatment for
haemorrhagic fever with renal syndrome (HFRS) caused by Hantaan virus in Asia. However …

We report that ribavirin exerts an inhibitory and mutagenic activity on SARS-CoV-2-infecting
Vero cells, with a therapeutic index higher than 10. Deep sequencing analysis of the mutant …

Flaviviruses constitute an increasing source of public health concern, with growing numbers
of pathogens causing disease and geographic spread to temperate climates. Despite a …

Whole-genome sequencing (WGS) of viruses from patient or environmental samples can
provide tremendous insight into the epidemiology, drug resistance or evolution of a virus …

This review summarizes briefly literature reports on nucleoside analogues containing five-
membered aglycones based on imidazole-4-carboxamide, 1, 2, 4-triazole-3-carboxamide or …

The high mutation rate of RNA viruses provides viral populations with the ability to adapt to
new environments but also makes them vulnerable to extinction due to the deleterious …