[HTML][HTML] Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease
Pan-betacoronavirus neutralizing antibodies may hold the key to developing broadly
protective vaccines against novel pandemic coronaviruses and to more effectively respond …
protective vaccines against novel pandemic coronaviruses and to more effectively respond …
A broad and potent neutralization epitope in SARS-related coronaviruses
Many neutralizing antibodies (nAbs) elicited to ancestral severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) through natural infection and vaccination have reduced …
coronavirus 2 (SARS-CoV-2) through natural infection and vaccination have reduced …
Broadly neutralizing antibodies against sarbecoviruses generated by immunization of macaques with an AS03-adjuvanted COVID-19 vaccine
The rapid emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants that evade immunity elicited by vaccination has placed an imperative on the …
variants that evade immunity elicited by vaccination has placed an imperative on the …
[HTML][HTML] Protection from SARS-CoV-2 Delta one year after mRNA-1273 vaccination in rhesus macaques coincides with anamnestic antibody response in the lung
M Gagne, KS Corbett, BJ Flynn, KE Foulds, DA Wagner… - Cell, 2022 - cell.com
Summary mRNA-1273 vaccine efficacy against SARS-CoV-2 Delta wanes over time;
however, there are limited data on the impact of durability of immune responses on …
however, there are limited data on the impact of durability of immune responses on …
A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy
Many SARS-CoV-2 variants have mutations at key sites targeted by antibodies. However, it
is unknown if antibodies elicited by infection with these variants target the same or different …
is unknown if antibodies elicited by infection with these variants target the same or different …
Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses
The emergence of current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants of concern (VOCs) and potential future spillovers of SARS-like coronaviruses into …
variants of concern (VOCs) and potential future spillovers of SARS-like coronaviruses into …
[HTML][HTML] Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability
Viral mutations are an emerging concern in reducing SARS-CoV-2 vaccination efficacy.
Second-generation vaccines will need to elicit neutralizing antibodies against sites that are …
Second-generation vaccines will need to elicit neutralizing antibodies against sites that are …
[HTML][HTML] Dissecting the intricacies of human antibody responses to SARS-CoV-1 and SARS-CoV-2 infection
R Wang, Y Han, R Zhang, J Zhu, X Nan, Y Liu, Z Yang… - Immunity, 2023 - cell.com
The 2003 severe acute respiratory syndrome coronavirus (SARS-CoV-1) causes more
severe disease than SARS-CoV-2, which is responsible for COVID-19. However, our …
severe disease than SARS-CoV-2, which is responsible for COVID-19. However, our …
Immunogenicity and protection of a variant nanoparticle vaccine that confers broad neutralization against SARS-CoV-2 variants
J Logue, RM Johnson, N Patel, B Zhou… - Nature …, 2023 - nature.com
SARS-CoV-2 variants have emerged with elevated transmission and a higher risk of
infection for vaccinated individuals. We demonstrate that a recombinant prefusion-stabilized …
infection for vaccinated individuals. We demonstrate that a recombinant prefusion-stabilized …
Multi-compartmental diversification of neutralizing antibody lineages dissected in SARS-CoV-2 spike-immunized macaques
The continued evolution of SARS-CoV-2 underscores the need to understand qualitative
aspects of the humoral immune response elicited by spike immunization. Here, we combine …
aspects of the humoral immune response elicited by spike immunization. Here, we combine …