Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

Advances in research and technology has increased our quality of life, allowed us to combat
diseases, and achieve increased longevity. Unfortunately, increased longevity is …

The nematode Caenorhabditis elegans has emerged as an important animal model in
various fields including neurobiology, developmental biology, and genetics. Characteristics …

Although the role of APP and PSEN genes in genetic Alzheimer's disease (AD) cases is well
established, fairly little is known about the molecular mechanisms affecting Aβ generation in …

Brain development crucially depends on the integrity of microRNA (miRNA) pathways, which
function at the post-transcriptional level as a rheostat of the transcriptome and proteome of …

Human brains retain discrete populations of micro RNA (miRNA) species that support
homeostatic brain gene expression functions; however, specific miRNA abundance is …

Abstract Type III RNase Dicer is responsible for the maturation and function of microRNA
(miRNA) molecules in the cell. It is now well-documented that Dicer and the fine-tuning of …

MicroRNAs (miRNAs) play essential roles in many physiological and pathological
processes, including tumor development, by regulating the expression of a plethora of …

The importance of various classes of regulatory non-protein-coding RNA molecules
(ncRNAs) in the normal functioning of the CNS is becoming increasingly evident. ncRNAs …

The contribution of mutations in amyloid precursor protein (APP) and presenilin (PSEN) to
familial Alzheimer's disease (AD) is well established. However, little is known about the …