Neurons of the mammalian central nervous system fail to regenerate. Substantial progress
has been made toward identifying the cellular and molecular mechanisms that underlie …

Peripheral nerves exist in a stable state in adulthood providing a rapid bidirectional
signaling system to control tissue structure and function. However, following injury …

We develop soft and stretchable fatigue-resistant hydrogel optical fibers that enable
optogenetic modulation of peripheral nerves in naturally behaving animals during persistent …

Peripheral nerves are organ-like structures containing diverse cell types to optimize function.
This interactive assembly includes mostly axon-associated Schwann cells, but also …

Various immune cells and cytokines are present in the aftermath of peripheral nerve injuries
(PNI), and coordination of the local inflammatory response is of great significance for the …

Sensory neurons located in dorsal root ganglia (DRG) convey sensory information from
peripheral tissue to the brain. After peripheral nerve injury, sensory neurons switch to a …

Macrophages originating from the yolk sac or bone marrow play essential roles in tissue
homeostasis and disease. Bone marrow-derived monocytes differentiate into Ly6Chi and …

In dorsal root ganglia (DRG), macrophages reside close to sensory neurons and have
largely been explored in the context of pain, nerve injury, and repair. However, we …

Background The important contribution of glia to mechanisms of injury and repair of the
nervous system is increasingly recognized. In stark contrast to the central nervous system …

Peripheral nerve injury (PNI) caused by trauma, chronic disease and other factors may lead
to partial or complete loss of sensory, motor and autonomic functions, as well as neuropathic …