Cell types are the basic building blocks of multicellular organisms and are extensively
diversified in animals. Despite recent advances in characterizing cell types, classification …

The development of the vertebrate eyes is a complex process starting from anterior-posterior
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …

Precise temporal control of gene expression in neuronal progenitors is necessary for correct
regulation of neurogenesis and cell fate specification. However, the cellular heterogeneity of …

During embryogenesis, optic vesicles develop from the diencephalon via a multistep
process of organogenesis. Using induced pluripotent stem cell (iPSC)-derived human brain …

In zebrafish, Müller glia (MG) are a source of retinal stem cells that can replenish damaged
retinal neurons and restore vision. In mammals, however, MG do not spontaneously re-enter …

Transplantation of rod photoreceptors, derived either from neonatal retinae or pluripotent
stem cells (PSCs), can restore rod-mediated visual function in murine models of inherited …

Lineage studies conducted in the retina more than 25 years ago demonstrated the
multipotency of retinal progenitor cells (RPCs). The number and types of cells produced by …

Gene regulatory networks (GRNs), consisting of transcription factors and their target sites,
control neurogenesis and cell-fate specification in the developing central nervous system. In …

Humans rely on visual cues to navigate the world around them. Vision begins with the
detection of light by photoreceptor cells in the retina, a light-sensitive tissue located at the …

The human retina fails to regenerate and cell-based therapies offer options for treatment of
blinding retinal diseases, such as macular degeneration and retinitis pigmentosa. The last …